no shock value, the seizure, rolled in eyes, that for real
Re: What chemical is this? Way more powerful then LSD!
« Reply #20 on: November 08, 2009, 03:52:33 PM »
Topic: What chemical is this? Way more powerful then LSD! (Read 490 times)
jon
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German
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Re: What chemical is this? Way more powerful then LSD!
« Reply #21 on: November 10, 2009, 01:08:08 AM »
I've read that some derivatives of LSD-25 are estimated to be 10 to 100 times more potent but no one makes them since the starting ingredient is LSD-25.
Sedit
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Re: What chemical is this? Way more powerful then LSD!
« Reply #22 on: November 10, 2009, 03:09:03 AM »
This honestly sounds like internet non sence to me German. If there where higher potancy compounds the vascular constriction would be extremely great as it is in the FLY compounds and also starting at LSD-25 for researchers of the time was of no concern what so ever and they experimented with many variations such as the acetyl forms yet all that I know of show a slightly if not marked decrease in potancy.
PS: Reading this thread again for the first time in a while I am down right SHOCKED that Jon really advocated someone throwing away drugs.... Im... Speechless........
PS: Reading this thread again for the first time in a while I am down right SHOCKED that Jon really advocated someone throwing away drugs.... Im... Speechless........
jon
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Re: What chemical is this? Way more powerful then LSD!
« Reply #23 on: November 10, 2009, 07:26:02 AM »
i've trhrown a lot of drugs away because of thier lethality.
no1uno
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Re: What chemical is this? Way more powerful then LSD!
« Reply #24 on: December 05, 2009, 10:18:50 AM »
Fuck me, I'm 41 pages into that thesis and F.U.C.K... Shit & Bejesus, they're dealing with that shit, on bovine GPCR'S( ) that change from all cis to all trans with light and using the conformation thereof to determine how drugs will bond? Without actually being able to see anything? All with fucking guesswork? Damn, I thought working out what the fuck was happening in a flask was hard...
) that change from all cis to all trans with light and using the conformation thereof to determine how drugs will bond? Without actually being able to see anything? All with fucking guesswork? Damn, I thought working out what the fuck was happening in a flask was hard...badger
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Re: What chemical is this? Way more powerful then LSD!
« Reply #25 on: March 11, 2010, 04:02:53 AM »
Fuck me, I'm 41 pages into that thesis and F.U.C.K... Shit & Bejesus, they're dealing with that shit, on bovine GPCR'S(
GPCR = G protein-coupled receptor. Your neurotransmitter receptors are all GPCRs, so studying interaction with GPCRs in animal models gives some low-level idea of the pharmacokinetics of the substances under study.
Tsathoggua
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Re: What chemical is this? Way more powerful then LSD!
« Reply #26 on: March 29, 2010, 05:03:42 AM »
Thats a bit innacurate, Badger, by far from all of our neurotransmitter systems are based around GCPRs, only metabotropic receptors are to begin with, as by default the GCPR is part of initiating second messenger intracellular cascades.
Take the likes of the ionotropic glutamate receptors NMDA, AMPA and KA, no g-protein coupling there.
No idea about the ionotropic delta-type GluRs though, they do not share a huge degree of sequence homology with NMDA/AMPA/kainate receptors, but its just an example.
Take the likes of the ionotropic glutamate receptors NMDA, AMPA and KA, no g-protein coupling there.
No idea about the ionotropic delta-type GluRs though, they do not share a huge degree of sequence homology with NMDA/AMPA/kainate receptors, but its just an example.