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re: Bioassay of fent!!!
Wed Jun 29, 2005 11:04 pm |
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ahh yes, its quite obviouse modesty is your strong suite
well good on you if you really did synth it, but i find the lack of any reference to your experience executing this synth rather suspicous, nor have i even explicitly heard exactly what route you took your yields or anything. i guess you did say you did the mannich rxn with pea and acetone but that only gives phenylethylpiperadone which is not fentanyl.
ive heard vague references to the mannich patent, another to some of the reagents which might be involved, none of which are exactly otc and many of which are closely watched, and finally another vague reference to siegfrieds method.
usually on a drug chemistry board it would seem to make some sense to cover synthesis part of your experience a little more and not just type alot about , whoa dude im so fucked up, im so smart and this was so easy.
but hey, im no moderator here |
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the alchemist
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| Joined: 23 Jun 2005 |
| Posts: 46 |
| Location: Planet Earth, Terran System |
1568.10 Points
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re: Bioassay of fent!!!
Thu Jun 30, 2005 12:27 am |
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| Yes, I agree that your bioassay is exciting but please take the time to write up your procedure... especially highlight the points where you had trouble. How are you sure that your material is pure? |
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eyesoftruth
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| Joined: 24 Jun 2005 |
| Posts: 11 |
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238.30 Points
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re: Bioassay of fent!!!
Thu Jun 30, 2005 12:32 am |
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no
Last edited by eyesoftruth on Fri Jul 08, 2005 9:22 pm; edited 1 time in total |
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re: Bioassay of fent!!!
Thu Jun 30, 2005 1:40 am |
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| ok i am sorry if i offended you. i did that deliberately but it was nothing personal against you. i hope that we can still be friends inspite of these degrading insults. remember that "in the real world" fentanyl is adminstered to terminally ill cancer patients and the like. it upsets that someone of your age would want to get involved in this type of illicit activity. moreover you came across as someone who was bullshitting. my main reason for believing this was that i wasn't even able to recover the patent that you made reference to. it may as well have been a spurious bunch of random numbers that came-off the top of your head. |
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eyesoftruth
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| Joined: 24 Jun 2005 |
| Posts: 11 |
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238.30 Points
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re: Bioassay of fent!!!
Thu Jun 30, 2005 2:11 am |
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no
Last edited by eyesoftruth on Fri Jul 08, 2005 9:22 pm; edited 1 time in total |
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lurker4711
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| Joined: 23 Mar 2005 |
| Posts: 44 |
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1546.56 Points
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re: Bioassay of fent!!!
Thu Jun 30, 2005 5:03 am |
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Bla, bla.
Fentanyl can be bought online - yes. The bioassay sounds true - a fast lane to addiction as it can be. The babble about the synth is just babble. Obviously. |
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Cyrax
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| Joined: 19 Mar 2005 |
| Posts: 8 |
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640.40 Points
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Re: re: Bioassay of fent!!!
Tue Jul 05, 2005 8:44 pm |
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| eyesoftruth wrote: |
Hello SWIM's writing this and not me. ok?
Anyway, SWIM wants to be as general as specific.
Preparation of starting compound:
React 1-benzyl-4-piperidone with aniline. Reduce condensation prod with lithium aluminum hydride. React the resultant product with Propionic Anyhidride and finally hydrogen.
Mix 1:
Dissolve NPP (5 parts), Sodium carbonate (6.85 parts), potassium iodided (.05 parts) in Hexane (120 parts).
Mix 2:
Dissolve Beta phenylethlchloride (3.8 prts) in 4-methyl-2-pentanone (24 prts).
Add Mix 2 dropwise into Mix 1 and then reflux for 27 hrs (SWIM saw no problem with just 24 hrs). NOTE: Best to use a 2 neck or 3 neck rb flask, a magnetic-stirrer/hotplate (1L capacity is ok), and either a dropper or an addition funnel. If you have patience, use a standard 2 ml pipette or dropper and add Mix 2 without the attached dropper or funnel. Then you could just use a standard rb flask and not need a 2 or 3 necked flask. Obviously bring heat up slowly and stir constantly.
Filter the mixture while still hot and evaporate the liquid on a steam bath.
Add diisopropyl ether (160 parts) tot the remains from previous step (which seems to be some sort of oil) and filter a few times (4 times or so) until clear.
Concentrate the solution and cool the liquid in the fridge to yield a white crystalline powder (which is fent).
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It is funny to see that this is just a re-phrasing of US patent 3141823 where you changed 5 parts N-(4-piperidyl)-propionanilide into 5 parts NPP (N-phenethyl-piperidone ?, why alkylate the piperidone ?). Caution: re-phrasing a patent & pretending it is your own work = fraud |
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re: Bioassay of fent!!!
Mon Jul 11, 2005 2:05 am |
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oops, be afraid
Last edited by nobodyimportant on Wed Jul 20, 2005 9:07 am; edited 1 time in total |
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stooge
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| Joined: 11 Feb 2005 |
| Posts: 56 |
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1401.36 Points
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re: Bioassay of fent!!!
Mon Jul 11, 2005 3:08 am |
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withdrawal evolves with each time, as strange that might sound.
Anyway, i'd expected worser symptoms than you descibed ...
good to hear some first hand experiences, sometimes.
**edit:
btw, how much did you use within those 2 weeks? |
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re: Bioassay of fent!!!
Mon Jul 11, 2005 4:21 am |
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| oops, be afraid |
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