E-Books available for download....

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Directed Molecular Evolution of Proteins : or How to Improve Enzymes for Biocatalysis

pages: 368 pages Publisher: Wiley-VCH ISBN: 3527304231
Summary:
Natural selection created optimal catalysts. However, optimal performance of enzyme catalysis does not necessarily refer to maximum reaction rate. Rather, it may be a compromise between specificity, rate, stability, and other chemical constraints that makes enzymes capable of catalyzing reactions under mild conditions and with high substrate specificity, accompanied by high regio- and enantioselectivity.
The book presented here focuses on the directed evolution of proteins, which has established itself as a powerful method for designing enzymes showing new substrate specificities. It includes a comprehensive repertoire of techniques for producing combinatorial enzyme libraries, while the functional gene expression in a suitable host helps in selecting the appropriate structure, making fast screening a necessity. This book illustrates both the theoretical background as well as the potential of this interesting method in practice - which is becoming ever more important even in classical organic synthesis!

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Introduction to Environmental Analysis (Analytical Techniques in the Sciences)
ISBN: 0471492949 Author: Roger N. Reeve
Publisher: John Wiley & Sons
Summary:
Provides information on the application of analytical techniques, such as GC, LC, IR, and XRF for analysing and measuring water, solid and atmospheric samples and for monitoring environmental pollutants.

* Emphasizes Field Analysis, reflecting the growing application of this technique
* Information on sampling strategies - reflecting growth in this area
* Includes sections on solid and liquid extraction techniques
* Ideal as a self-study aid or as a taught course

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Bioanalytical Chemistry by Susan R. Mikkelsen and Eduardo Corton
Wiley-Interscience 2004 ISBN 0-471-54447-7 384 pages February 2004
Wiley List Price: US $99.95

Bioanalytical Chemistry provides a thorough introduction for students and practitioners with a broad range of backgrounds from chemistry to medicine. In so doing, it brings together many of the techniques commonly used by biochemists and molecular biologists. The text includes entire chapters on design and implementation of enzyme assays; mass spectrometry; and validation of new methods. Each chapter progresses from basic concepts to applications involving real samples, and ends with a set of problems, while an appendix contains selected answers. The authors have limited mathematical derivations to those that are essential for an understanding of each method and they include a list of suggested reading for further information. This textbook provides an ideal companion for students, researchers, and industrial scientists working in chemistry, biology, biochemistry, pharmacy, and medicine.

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Multidimensional Chromatography
Size: App. 4.7 MB

# Hardcover: 448 pages
# Publisher: John Wiley & Sons (October 15, 2001)
# Language: English
# ISBN: 0471988693

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Modern Electrochemistry
Great Electrochemistry Series!, March 27, 2005
These authors have a great writing style. This is a subject matter that has a potential to be very, very dry but the authors have somehow made it enjoyable. If they get into hardcore calculations and derivations that you might be a little rusty on, they anticipate that (I assume from lots of students' feedback) and include appendixes at the end of each chapter so that you don't need to run off and find the corresponding chapter in one of your math/physics/chemistry textbooks. They also have a very useful nomenclature guide (in the first book only) in case you keep forgetting what certain symbols mean and what units they are in. The footnotes are great and keep things from getting too dry. Overall, I would definitely recommend these three books.

Note: There are three books in this series.
Electrochemistry 1: Ionics
ISBN: 0306455552 (paperback)

Electrochemistry 2A: Fundamentals of Electrodics
ISBN: 0306461676 (paperback)

Electrochemistry 2B: Electrodics in Chemistry, Engineering, Biology, and Environmental Science
ISBN: 0306463253 (paperback)

Links For other 2 books I dont know

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The $800 Million Pill : The Truth behind the Cost of New Drugs
by Merrill Goozner

In this fascinating critical look at drug and biotech companies, Goozner pulls back the curtain on the process of new drug development and answers two important questions: "where do new drugs come from?" and "what do they cost to invent?" Using case studies that recount the discovery, development and eventual commercialization of a number of significant drugs, including Epogen and the AIDS cocktail, Goozner dismantles the pharmaceutical industry’s assertion that drug prices must be kept high in order to stimulate cutting edge research. The cost of each new discovery averages $800 million, industry officials have claimed. But Goozner argues that citizens are already paying much of that bill: taxpayer-financed medical research, he finds, has played a major role in each important medical discovery. Goozner convincingly argues that new drugs get into the hands of the sick not thanks to drug and biotech companies, but to the passion of dedicated scientists—in both the private sector and the public. A former Chief Economics Correspondent for the Chicago Tribune and an award-winning journalist, Goozer writes with skill and elegance, incorporating anecdote and history in a way that enlivens his research and makes his book an engrossing read. Though the issue of drug costs has been discussed extensively in the media, Goozer’s study puts all the political chatter, news coverage and analysts’ reports into a context where they finally make sense.

From the New England Journal of Medicine, July 22, 2004
The pharmaceutical industry claims that it can continue playing a key role in the development of new weapons against disease only if Americans pay prices for medicines that yield very high profits. It also claims that price controls would cause the stream of new products to dry up. Merrill Goozner, a former chief economics correspondent at the Chicago Tribune, comes to a conclusion that is very different from the views espoused by the drug companies. He does so on the basis of a detailed review of the development of drugs to combat cancer and the human immunodeficiency virus, a description of the early successes of therapies developed by the biotechnology industry, and a review of the economics of "me-too" products, such as H(sub 2) antagonists, proton-pump inhibitors, and allergy medications. He believes that the private sector's main role is to develop and commercialize therapies that are based on knowledge generated by independent researchers in academia and in government. In his opinion, high prices and big profits are not the key ingredients in pharmaceutical breakthroughs. On one hand, this book gives the reader lots of interesting and useful background about the people and organizations involved in expanding medical knowledge and in developing drugs. On the other hand, it falls short of what I expected from the title. It is not a detailed forensic accounting of the true cost of developing individual drugs as compared with industry claims. Indeed, the only real discussion of the $800 million pill (the alleged average cost of developing a new drug in the United States) comes in a brief review of a study by the Tufts University Center for the Study of Drug Development that was first published in 1991 and then updated in 2001. There is a brief rebuttal from other organizations in the penultimate chapter of the book, but for a reader looking for definitive "proof" or data, this book falls short. Written in the typical style of investigative journalism, the book comes across as an author's attempt to prove a point, rather than an impartial scientist's effort to answer a question. Goozner repeatedly comes back to one central theme: that medical innovations start with dedicated and passionate people, most of whom are not employed by the pharmaceutical industry, who are investigating scientific questions. Without these dedicated scientists, none of the innovations described in this book would have occurred. In other words, the development of drugs is not exclusively driven by high profits but, rather, is a collection of efforts. Goozner goes on to suggest some very useful methods for improving the process of drug development with the support of government-funded research (e.g., randomized trials comparing new and existing products, such as the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, known as ALLHAT). Although the approach Goozner uses in this book is not scientific, I think he makes a persuasive case. The passion of individual scientists pursuing an activity they truly enjoy, not the profit motive, has led to the major technological advances of the past century. I will end by saying that I am not one who enjoys reading books slowly. I often skim. In order to read a book from cover to cover, I have to find it truly interesting. I can tell you that I read every word of this book. Allan S. Detsky, M.D., Ph.D.

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Thin Layer Chromatography djvu

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I know this is not chemistry-related strictly speaken. RAW's modus operandi is tho. I'd love to share "Sex, Drugs & Magick" with you but I just havent got the time (or the scanner) to scan the hardcopy available right here next to me. So, this is what you're left with....

http://rapidshare.de/files/3009050/Robert_Anton_Wilson_-_Prometheus_Rising.pdf.html

Use those drugs responsibly. They wont help on your road to enlightenment - rather the opposite in fact - but they make it fun.

Note: thanks to sbrothy for aquiring the book

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Gale Encyclopedia of Medicine, Second Edition

Consult the second edition of this authoritative, comprehensive, in-depth medical guide for information on more than 1,700 medical topics in language accessible to adult laypersons. Presented in a single alphabetical sequence, articles range in length from one or two paragraphs for minor topics, to several pages or more for major topics. Disease/disorder articles typically cover definition; description; causes and symptoms; diagnosis; treatments; prevention; and more. Test/treatment articles typically cover definition; purposes; precautions; preparation; risks; normal and abnormal results; and much more. This second edition includes more than 200 new entries, 300 updated entries, approximately 650 color images and illustrations, and a comprehensive subject index. New features include biographical and historical sidebars throughout the text

5 parts:

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Note : thanks to now for aquiring the books

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Enzyme Kinetics : A Modern Approach

ISBN: 0471159859 Author: Alejandro G. Marangoni Publisher: Wiley-Interscience
Summary:
Practical Enzyme Kinetics provides a practical how-to guide for beginning students, technicians, and non-specialists for evaluating enzyme kinetics using common software packages to perform easy enzymatic analyses.
Table of contents:
Tools and techniques of kinetic analysis — How do enzymes work? — Characterization of enzyme activity — Reversible enzyme inhibition — Irreversible enzyme inhibition — pH dependence of enzyme-catalyzed reactions — Two-substrate reactions — Multisite and cooperative enzymes — Immobilized enzymes — Interfacial enzymes — Transient phases of enzymatic reactions — Characterization of enzyme stability — Mechanism-based inhibition / Leslie J. Copp — Putting kinetic principles into practice / Kirk L. Parkin — Use of enzyme kinetic data in the study of structure-function relationships of proteins / Takuji Tanaka and Ricky Y. Yada.

ayhan · Tue Aug 02, 2005 1:57 pm

Does anybody know ebooks,handbooks concerning with fatty acids derivatives,[/b][/url]

noflame · Wed Aug 03, 2005 8:33 pm

this volume has been deleted can somebody re-up please

http://rapidshare.de/files/3118153/Gale_Encyclopedia_of_Medicine._Vol._4._2nd_ed.pdf.html

ayush · Fri Aug 05, 2005 11:09 am

The Biomedical Engineering Handbook 2Ed
Size: 51 MB. May not be available for long time. Interested members hurryup and also upload to Rapidshare.
http://www.megaupload.com/?d=30ISXK94

ayush · Fri Aug 05, 2005 11:34 am