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4-Amino-4-arylcyclohexanones and Their Derivatives: A Novel Class of Analgesics. 2. Modification of the Carbonyl Function
Daniel Lednicer,' Philip F. VonVoigtlander,* and D. Edward Emmert
Journal of Medicinal Chemistry, 1981, Vol. 24, No. 4, pg. 404

http://rapidshare.de/files/5560861/jm00136a010.pdf.html

Abstract
The effect on potency of modification of the carbonyl function of analgesics derived from 4-(dimethylamino)-4-
arylcyclohexan-1-one was studied by reduction and by addition of nucleophiles. The resulting amino alcohols were
separated and assigned structures on the basis of X-ray crystallography, NMR, and TLC mobility. The trans (OH
and N) isomers were invariably more potent than the cis. Inclusion of flat lipophilic moieties (phenyl, cyclohexenyl)
at a distance of at least two carbon atoms from the carbon bearing hydroxyl led to increases in potency by orders
of magnitude. The possible significance of this on receptor interaction is discussed.

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Reduction of Organic Compounds with Sodium Borohydride-Copper(II) Sulfate System
Sung-eun Yoo, Sang-hee Lee
Synlett, 1990, 419-420
http://dx.doi.org/10.1055/s-1990-21113
http://rapidshare.de/files/5388564/Synth._Lett.__1990__419-420_.pdf.html

Abstract: The reduction of various functional groups was investigated using sodium borohydride-copper(II) sulfate. Ketones, aliphatic esters, olefins, nitriles and aliphatic and aromatic nitro groups were reduced, but amides, aliphatic and aromatic carboxylic acids wre inert. Rate of reaction was different for the various functional groups, allowing selective reductions to be performed.

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Effect of bacoside A on membrane-bound ATPases in the brain of rats exposed to cigarette smoke
K. Anbarasi, G. Vani, K. Balakrishna, C. S. Shyamala Devi
J. Biochem. Mol. Toxicol., 2005, 19(1), 59-65
http://dx.doi.org/10.1002/jbt.20050
http://rapidshare.de/files/5401792/J._Biochem._Mol._Toxicol.__2005__19_1___59-65.pdf.html

Abstract: Membrane-bound enzymes play a vital role in neuronal function through maintenance of membrane potential and impulse propagation. We have evaluated the harmful effects of chronic cigarette smoking on membrane-bound ATPases and the protective effect of Bacoside A in rat brain. Adult male albino rats were exposed to cigarette smoke for a period of 12 weeks and simultaneously administered with Bacoside A (the active principle isolated from Bacopa monniera) at a dosage of 10 mg/kg b.w/day, p.o. The levels of lipid peroxides as marker for evaluating the extent of membrane damage, the activities of Na+/K+-ATPase, Ca2+-ATPase and Mg2+-ATPase, and associated cations sodium (Na+), potassium (K+), calcium (Ca2+), and magnesium (Mg2+) were investigated in the brain. Neuronal membrane damage was evident from the elevated levels of lipid peroxides and decreased activities of membrane-bound enzymes. Disturbances in the electrolyte balance with accumulation of Na+ and Ca2+ and depletion of K+and Mg2+ were also observed. Administration of Bacoside A inhibited lipid peroxidation, improved the activities of ATPases, and maintained the ionic equilibrium. The results of our study indicate that Bacoside A protects the brain from cigarette smoking induced membrane damage.

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The Preparation of Ketones from Nitrobleiins
DOROTHNYIG HTINGAALNED J. R.J ANES’
J. Am. Chem. Soc., 1944, 66(), 352-354

http://rapidshare.de/files/5531097/ja01231a009.pdf.html

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Labi · Fri Sep 30, 2005 10:34 pm

my best wishes to all those doing this great work for Chemistry. if any one is in need of any full text reference from "phytochemistry" please post me a message i will try to provide the pdf file. note only from vol 43 to 65. all the best once again and keep up the good work going

Very Happy

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Heterogeneous catalysts in the preparation of 2-aryl-1,3-dinitropropanes from beta-nitrostyrenes or benzaldehydes
Fierro A.; Rezende M.C.; Seplveda-Boza S.; Reyes-Parada M.; Cassels B. K.
J. Chem. Res. (S), 2001, 7, 294-296

http://rapidshare.de/files/5823419/J._Chem._Res.__S___2001__7__294-296.pdf.html

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