Selective and Rapid Oxidation of Alcohols

stratosphere · Sat Jun 25, 2005 6:07 am

thank you very much epck.
it doesn't sound to bad,
neccassary reagents (o-pathalic acid, hydroxylamine, Co(OAc)2) are easy to come by , yields are high(92%), and reaction time very reasonable(~2hours), it looks as though the m-chlorobenzoic acid can be skipped and air can be used in place of pure oxygen (with a corresponding decrease in yield of about 10%, although i wonder if increasing reaction time would remedy this)

i also wonder if replacing MeCN with another aprotic polar solvent (e.g dmf) would give as good of yields.

pharmakon · Thu Jun 30, 2005 9:34 pm

another article which might be interesting to read:

Selective oxidation of secondary alcohols
Jeffry B. Arterburn, Tetrahedron, 2001, 57, 9765-9788

maybe someone can find and post it ?

epck · Thu Jun 30, 2005 11:38 pm

Here's that one as well. http://www.uploadtemple.com/view.php/1120154733.pdf

pharmakon · Sat Jul 02, 2005 2:05 am

Thank you very much, epck.
I'm a bit shy to ask for more Embarassed

Theres just one article Rolling Eyes

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