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Total 4-FA synthesis using Al/Hg reduction
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IndoleAmine
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Sat Apr 16, 2005 3:20 am
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Margaret_Thatcher: Would you be so kind and add a few more words to your post as to form at least one understandable sentence with it, please?

Thanks.
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Star-light
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Sun Apr 17, 2005 7:20 pm
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IndoleAmine wrote:
Just for clarifying: I said that you probably don't feel much empathogenic qualities of said substance when you take as much as 150mg or more, and that less is more in this case (and I suggested a dose of at most 100mg).


You need to take 200-250mg (80kg adult) in order to get the best effects of this compound. It is indeed empathogenic (although not wildly so). At a dose of 100mg or 130mg its effects are boring, and not worth the bother.

A 200-250mg dose will probably give some muscle tension however.
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IndoleAmine
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Mon Apr 18, 2005 12:27 am
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So its more feeling like a stimulant after all, and not even a strong one?
(and I thought it was great fun..)

With amphetamines in general, taking large amounts usually produces side effects like mucle tension, jaw clenching, elevated blood pressure etc., and the less you take, the more pronounced other effects become (should there be any). Thats why I suspected 150mg would be a bit much.

If you need that large amounts for having fun with it, I would say there's no way around feeling more stimulated than socialized... Laughing
(even plain *mphetamine does produce effects at lower doses! Is this compound really that special that its effects justify a double body load of neurotoxins for having only slightly more fun?)


i_a
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Star-light
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Mon Apr 18, 2005 1:16 am
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IndoleAmine wrote:
So its more feeling like a stimulant after all, and not even a strong one?
(and I thought it was great fun..)


It is pretty good fun. It has a different feel to amphetamine and methedrine. Great if you are going out to a party and intend to have a couple of drinks.

The drinks are the way around feeling too much body stimulation.
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mind

Joined: 10 Feb 2005
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Mon Apr 18, 2005 2:03 am
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Star-light wrote:
IndoleAmine wrote:
Just for clarifying: I said that you probably don't feel much empathogenic qualities of said substance when you take as much as 150mg or more, and that less is more in this case (and I suggested a dose of at most 100mg).


You need to take 200-250mg (80kg adult) in order to get the best effects of this compound. It is indeed empathogenic (although not wildly so). At a dose of 100mg or 130mg its effects are boring, and not worth the bother.

A 200-250mg dose will probably give some muscle tension however.

Star-light:
do you have any tolerance for amphetamine's?

and maybe a mod can split this topic, 1 for the chemistry discussion and 1 for the pharmacology...
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64bandil
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Mon Apr 18, 2005 2:29 am
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150 mg's of the hydrochloride is not enough
200 mg's is juuuust right
300 mg's is too much - not comfortable...

Seems that all of my friends agree with these dosage Wink
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sony

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Mon Apr 18, 2005 4:43 am
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Amen brother, 150 mg 4-fla hydrochloride supplemented by another 50 mg 2 hours later is definately viking certified.
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Star-light
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Mon Apr 18, 2005 9:54 pm
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mind wrote:

Star-light, do you have any tolerance for amphetamine's?


No, I have no tolerance for amphetamines.
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MargaretThatcher

Joined: 16 Feb 2005
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Tue Apr 19, 2005 7:25 am
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Maybe mg/Kg would be a better description of dosage.
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Vitus
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Thu Apr 21, 2005 2:27 am
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Quote:

"Feeling of emptyness and melancholy was pronounced, which I experience from MDMA as well." ...time to give your synapses a break maybe... (no offense)

(sounds like some serotonergic compound though, kinda at least)



I've tried 4-FA a couple of times in moderate doses (50mg-100mg) by insufflation, and the strange thing is that the effects for me ranged between the strangely mellow effects described by ms. Tatcher and the melancholic effects described by herr Sandmeyer for N-Et-4-FA. I never could compare it to amphetamine.

I only use compounds moderately so my synapses have a lot of rest, but the last time I tried 4-FA it triggered a full-blown depression that lasted for quite some time.

I must add that I do not believe this was only caused by 4-FA, as I tend to be melancholic quite often and especially in the middle of the winter, which was when this episode occured.

The 4-FA was of pristine purity and used as the hydrogen sulfate salt (which is not so soluble in water and is therefore not so pleasant in the nose).
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IndoleAmine
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Thu Apr 21, 2005 2:53 am
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The hydrosulfate is less soluble in H2O than the diamine sulfate? Normally its the other way round...
(IME any sulfates simply are painful when snorted, compared to hydrochlorides - must be more related to the SO4(2-) than to solubility, if you ask me)
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Vitus
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Thu Apr 21, 2005 3:56 am
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my mistake, it was of course the diamine sulfate Embarassed
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MargaretThatcher

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Thu Apr 21, 2005 5:47 am
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A couple of times 100 mg FA.HCl

Long lasting with no hangover for me. Strange stuff. None of that jittery, tweaky feeling and did not want nor need to sleep. None of the absurd lovey-dovey feeling that MDMA gives. I can only describe it as mellow and friendly. I'd like to see it tested on a few other primates before I try it too often.

Edit: I was brief before because I did not want to give an Erowid-style tweaker report. I have now. May the Lord look with forgiveness upon my misdeed.
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tetraedr

Joined: 16 Feb 2005
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Thu Apr 21, 2005 9:01 am
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SWIM has got the NMR-specrtum of 4-FA. It looks almost pure (no more 2-3%) of admixtures and as a right compound.

NMR-1H (DMSO-d6) ppm: 1.11 d (3H, Me), 2.65-2.72 m (1H, CHa), 3.04-3.09 m (1H, CHb), 3.36 bs ( CH+water), 7.11-7.16 m (2H, Ar-CH), 7.27-7.31 m (2H, Ar-CH), 8.30 bs (3H, NH3+).

And now SWIM is going to test it himself, on the weekend.
Could you remind me about duration of this stuff? If SWIM takes it (intramuscularly, perhaps) - 150-200 mg, in the morning. After what time he can sleep? Can drive the car?
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Sandmeyer

Joined: 25 Mar 2005
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Fri Apr 22, 2005 4:20 am
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IndoleAmine wrote:
time to give your synapses a break maybe... (no offense)


Thanks for the concearn, but MDMA-kind-of-drug was several years ago I used, and I only did it couple of times, never liked it, so my synapses are doing well.

Quote:
AFAIK lenghtening the n-alkyl chain does result in diminished activity (MDxA and n-methylphenylisopropylamine are exceptions to this rule, the only common substances where n-methylation enhances activity).


MDMA compounds have unique psychopharmacology, hence it makes no sence to compare their SAR to others in Pihkal. (funny, you can't write m.e.t.h w/o "." it gives "----", is this feature supposed to make us DEA-immune or something, LOL?)


Last edited by Sandmeyer on Fri Apr 22, 2005 4:39 am; edited 2 times in total
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