Synthesis of mescaline using Al/Hg reduction

IndoleAmine · Dreamreader Deluxe

A funky polymer probably? Very Happy

But it sounds a bit like residual nitrostyrene which polymerizes when hit with anhydrous mineral acids, if you ask me....
(purity tlc confirmed b4 acidifying?)

jory · Mon Apr 25, 2005 10:52 pm

IndoleAmine · Dreamreader Deluxe

IndoleAmine · Dreamreader Deluxe

-ggg-

tom-a-rom-rinbow · Sat May 07, 2005 12:59 pm

does the oxone bromination work more easily on impure 2c-h?

IndoleAmine · Dreamreader Deluxe

IndoleAmine · Dreamreader Deluxe

IndoleAmine · Dreamreader Deluxe

-ggg-

spicybrown · Tue Jun 28, 2005 7:42 am

2........2,5-Dimethoxyphenylnitropropene........99 (solvent)..failed...........92

Somebody I know successfully prepared 2,5-dimethoxyamphetamine from 2,5-dimethoxyphenylnitropropene using Al/Hg reduction. Don't recall the yields right this minute, but they weren't great, not terrible either. DOB was successfully prepared from the resulting dimethoxyemphatemine following nothing more than an acid/base extraction for purification. The resulting dimethoxyamphetamine HCl appeared to be a very viscous oil. Initially, roughly half of the material was taken onwards to DOB. The other half was left in a dark box in a basement for several months. When it was again looked upon it had all crystalized to a tan solid, which once again successfully yielded DOB upon bromination with Br2 in glacial HOAc.

-SpicyBrown

64bandil · Busy Bee

I got about 80% 2,5-DMA.HCl from reduction of 2,5-DMP2NP on Al[Hg]. Batch size was 10 g nitropropene. Everything was steam distilled directly out of the Al sludge and crystallized. Very pure etc - brominated like a charm Very Happy

icecool · Insistent Chemist

Please tell us more about the Al/Hg ratio's and the foil etc.
Very curious since SWIM get's shitty yields most of the time with amphetamine 25% and 2C-B only 2mg out of 5g nitrostyrene, dunno what happened after the 2C-H was rotavapped (distilled off the toluene) nothing happened when adding it to GAA and no heat and no crystals.
Does the toluene intervent this, next time I'll distill off the last bit of toluene with normal distillation so that it is more pure 2C-H.
Is it also possible to steam distill out the 2C-H since you were talking about the synthesis of DOB...