4-Methyl Fentanyl

[Anansi]

There was some interest in the .PDF Journal Article I posted regarding synthesis & pharmacology of Longer Acting Fentanyl Analogues.

I also have the .PDF for a journal article regarding the synthesis & pharmacology of 4-Methyl Fentanyl. This analogue is approximately 3x the potency of Fentanyl and has significantly better confidence limits. The journal article is by I.V. Micovic et al. - the same group who published the article about 2,3-secofentanyl available at Rhodium's site.

In this article this article they use a different method to the more common N-alkylation of 4-piperidone, formation of imine derivative of N-alkylpiperidone followed by reduction of imine derivative etc. The method presented is also suitable for the synthesis of other 4-substituted fentanyl derivatives, which range between 2x and 30x the activity of Fentanyl.

I don't have the ability to put the .PDF online, but if bees express some interest in this article I can email it to Rhodium, who can make it available.

...Anansi

[ChemisTris]

What is the title of the paper, and what journal does it appear in?
Thanks  
Got democracy?

http://www.dhushara.com/book/multinet/democ/wed.htm

[blondie]

Anansi, blondie would be interested in the pdf, i think it would also make a good addition to Rhodium's archive.

[Cyrax]

The title is: 'The synthesis and preliminary pharmacological evaluation of 4-methyl fentanyl' and the article appeared in 'Bioorganic & Medicinal Chemistry Letters (2000) vol 10 p 2011 - 2014'

[Rhodium]

https://www.thevespiary.org/rhodium/Rhodium/pdf/4-methyl-fentanyl.pdf