Psilocybin

[Damien_Thorne]

Call me dumb, but I was just wondering if there was a method out there which would enable me to synthecize psilocybin.  Mushrooms have always been among a favorite of my trips.

=>I am a firm believer in my Constitutional Right to the Pursuit of Happieness<=

[Rhodium]

These are probably the best methods available:

http://rhodium.lycaeum.org/chemistry/psilocybin.html

http://argon.ch.ic.ac.uk/ectoc/echet98/pub/039/index.htm

http://rhodium.lycaeum.org

[Mr_Smith]

Why synthesize when you can just grow the darn things?

[sunlight]

Do you know what is the regioselective thallation of the 4-position and how to make it ?
I think that a good way could be attack directly DMT in 4 position and then make the acetoxy, in Psychedelic chemistry, Michael Valentine gives a rxn with H2O2 and Cu Sulfate (don't remember exactly) that yields a mixture of different OH DMT, taht can be separated with chromatography, what do you think about it ?
This regioselective thallation seem to be be better.

[Lilienthal]

Thallium?    It's extremely toxic and it's polluting the environment. Bad idea. Other 4-hydroxylation reactions have low yields or need many steps. You can find the literature references on my site:

Lilienthals References

(http://www.fortunecity.com/westwood/storey/116/).

[Mr_Smith]

Awww, but it's just not a trip unless your eyebrows fall out!!!

[KrZ]

[sunlight]

Lilienthal, don't you know the hydroxylation in Psychedelic Chemistry ? a 30 % yield seems good.