Is there any method...

[malvaxman]

Is there any method to make pure enantiomeric d-meth which doesn´t involve natural products like l-ephedrine l-PAC?

....i guess the method which ofcours exists could be applicable in some research fascility but deffinitly not my kitchen or garage.  

/Thank you for your help

[Rhodium]

https://www.thevespiary.org/rhodium/Rhodium/chemistry/amphetamine.resolution.html

[PrimoPyro]

There are also likely to be other possibilities involving organometallic syntheses. Many chiral agents have been developed for many syntheses involving these reactions. More information, I cannot produce, this is essentially all I know. My source (March's 5th) was very vague, and only consisting of about two sentences stating what I already stated.

Many of these catalysts revolve around the syntheses of alcohols and amines, so it is likely that such methods exist and are applicable here. What they are, I do not know as of yet.

                                                   PrimoPyro
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[lugh]

You can also use reductive alkylation using methylbenzylamine as found in:

https://www.thevespiary.org/rhodium/Rhodium/chemistry/reductive.alkylation.html

Reductive Alkylation of alpha-Methylbenzylamine with 1-Phenyl-2-Propanone Followed by Hydrogenolysis:

Nichols et al., Asymmetric Synthesis of Psychotomimetic Phenylisopropylamines, J. Med. Chem. 16(5) (1973) 480-3. This procedure offers a route to dextro-amphetamine from phenyl-2-propanone

[Rhodium]

Synlett 651 (2002) has a large review article of stereospecific addition of organometallic reagents to imines to form optically pure amines. It even includes some 2,5-dimethoxyphenyl compounds.

[PrimoPyro]

99% ee? Does that mean 99% enantiomerically efficient by any chance? Just a wild guess.
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[Rhodium]

Enantiomeric excess. A racemic mixture is 0% ee, and a pure optical isomer is 100% ee. A 99% ee mixture consists of 99.5% of one isomer and 0.5% of the other. Stupid unit, I know.

[PrimoPyro]

I will remember this. The unit is ok, its value reminds me of the Proof system for alcohols, also redundant.

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