methphenidate synth

[elosejohn]

[Rhodium]

The spelling "methylphenidate" may aid you in your searches.

Also see the following article:

Approaches to the Preparation of Enantiomerically Pure (2R,2'R)-(+)-threo-Methylphenidate Hydrochloride
Mahavir Prashad

Adv. Synth. Catal. 343(5), 379-392 (2001)

(https://www.thevespiary.org/rhodium/Rhodium/pdf/threo-methylphenidate.pdf)

Abstract
Various approaches to the preparation of enantiomerically pure (2R,2'R)-(+)-threo-methylphenidate hydrochloride (1) are reviewed. These approaches include synthesis using enantiomerically pure precursors obtained by resolution, classical and enzyme-based resolution approaches, enantioselective synthesis approaches, and approaches based on enantioselective synthesis of (2S,2'R)-erythro-methylphenidate followed by epimerization at the 2-position.