PPA from MEK and Benzaldehyde?

[ahgreich]

I have UTFSE until I'm BITF, but I clearly recall seeing some discussion re: cross-aldol condensation using mek+benzaldehyde to get ppa, or something very similiar to that reaction. Please help! am I delusional?

[Rhodium]

You are probably confusing

Post 428632

(Rhodium: "Piperonal + MEK -> Isosafrole?", Novel Discourse) with another post, possibly

Post 438325

(Rhodium: "Norpseudoephedrine synthesis & optical resolution", Methods Discourse).

[BOS]

I think you are thinking of this little gem by Twodogs:

Post 245942

(twodogs: "New method for P2P", Novel Discourse) P2P, aldol, MEK, benzaldehyde ect.
Nice aint it?

b

[ahgreich]

Found the benzylaldehyde + alanine=PPA, seems simple with the exception of removing the benzylamine byproduct from the final product - What do bees think about P2P by taking the crude PPA with benzylamine , covering with toluene, hydrolyzing with H2S04/ZnCl,separating, and evapping the toluene? Will the benzylamine hydrolyze into anything that will be taken up in the toluene? Is this a reasonable route to P2P?

[Aurelius]

Have you seen this ?  Post your latest tests results- etc. 

(if you would that is)