Sorry jon, I don't swing that way, besides, my other half would no doubt disapprove :p

But yeah, that botched MPPP synthesis did a real number on the users, after short period of use, the MPTP contaminated product started causing shaking of the extremities, rapidly progressing to near total immobility, lack of ability to speak or swallow, mentally perfectly alert and aware, just locked in their own bodies, as a drooling, paralyzed mess.

Doctors at first thought they were looking at end-stage parkinson's, in a subject that had had the disease for decades. Poor bastards couldn't even take a shit on their own.

You fuck up with one of those prodine reverse esters and get the dehydration product, your life, or what is left of it, isn't going to be worth living, end result is getting left as an mute, immobile drool monkey.

How to deal with it?

Nothing much left except sit there and hope to choke to death on your own saliva sooner rather than later.

Only way I would touch any of those drugs is after long and extensive high-dose bioassay trials on a large cohort of muslims before dosing, after letting at least a month of constant dosing be observed in the test rodents. In fact, I wouldn't try the stuff even thorough testing on vermin, as a lack of parkinsonian symptoms wouldn't preclude the presence of mere traces of MPTP (or homologs thereof) causing (at the time) subclinical damage to the substantia nigra.

Testing on standard lab animals wouldn't work, even if it wasn't inhumane, rats aren't affected by MPTP, possibly due to lower amounts of MAO-b in the murine brain, mice do lose nerve tissue in the substantia nigra but apparently fail to develop parkinsonian symptoms. Primates are responsive, but testing on a sentient animal would be unforgiveably cruel.

h**p://www.btscene.com/details/1690242/

Torrent link to the video documentary about users who got fucked by MPTP.

Eventually some of them were helped, I think in some cases tissue grafts were used, in others deep brain stimulation was used.

The rxn MUST be run cold, as cold as possible, otherwise the intermediate alcohol dehydrates to lose propionic acid, leaving one with MPTP.

Not sure if small amounts are produced regardless, but the hotter it gets, the more MPTP gets produced.
Not worth it in my opinion, there are so many other opiates one could produce instead that don't entail the risk of producing something that is going to leave you a vegetable if you fuck up.