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Author Topic: NITROETHANE SYNTH, given by Anon  (Read 1778 times)

lugh

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Re: NITROETHANE SYNTH, given by Anon
« Reply #80 on: April 01, 2011, 03:26:08 AM »
Quote
what purpose would lithium carbonate serve?

It's for ion exchange  8)
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no1uno

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Re: NITROETHANE SYNTH, given by Anon
« Reply #81 on: April 01, 2011, 04:16:54 AM »
Convert the nitrite (calcium nitrite is the easiest to acquire) to lithium nitrite, which is more soluble in many solvents.
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atara

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Re: NITROETHANE SYNTH, given by Anon
« Reply #82 on: April 01, 2011, 08:31:54 AM »
Rather than problematic Sandmeyer on alanine, just use the Lucas reaction with lactic acid (available in the form of calcium lactate dietary supplements) to generate your chloropropionate... then react with nitrite.

Also improves your nitroethane / nitrite yield, which is good because nitrite can be a bitch to obtain.

no1uno

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Re: NITROETHANE SYNTH, given by Anon
« Reply #83 on: April 01, 2011, 11:37:33 AM »
Nitrite isn't hard to obtain at all - have a look for calcium nitrite, it is used to harden cement (amongst other uses). In terms of the Lucas Reaction on Lactic acid, I'd be very interested to see the reports on that, alkylation of methylamine with 2-chloropropionic acid (etc) would give N-Methylalanine which an awful lot of people are interested in.
« Last Edit: April 01, 2011, 11:39:29 AM by no1uno »
"...     "A little learning is a dang'rous thing;
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..."

J20C

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Re: NITROETHANE SYNTH, given by Anon
« Reply #84 on: April 01, 2011, 05:49:06 PM »
I think lithium carboante just acts as a base catalyse, as alkylations seem to go faster in base environments.

Also, I found someone who pull edthat journal I linked in my above post, and it turns out it's in french, but that the rough translation is the switching methyl tosylate for ethyl tosylate will give nitrethane as well. I can post the abstract and the whole article if anyone wants, though again, it's in french, and my translation is VERY basic.

"
186 grams Methyl Ester of p-Tosic Acid, was mixed with 69 grams of sodium nitrite. Left to chill, and nitromethane was formed, with water and sodium sulfate being the main side products left, it was distilled off for collection, and replacing the methyl ester with ethyl ester, resulted in nitroethane being obtained :) "

Wizard X

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Re: NITROETHANE SYNTH, given by Anon
« Reply #85 on: April 01, 2011, 10:11:45 PM »
Lucas reaction with lactic acid methyl ester => Methyl-2-chloropropionate. http://www.caslab.com/Methyl-2-chloropropionate_CAS_17639-93-9/
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