Thanks, was looking back at dingbow his posts and I think the 5.6 gr of TCCA with 5 gr amide is making a bit of Chloro...
Will work on the reflux NaOH thingie ;-)
Will work on the reflux NaOH thingie ;-)
Hey Guys,
I want to see if theres a way to skip the relatively messy aldehyde to amide steps we see in the commonly accepted method.
One of the two papers details a reaction that converts piperonal to methylenedioxybenzamide using copper sulfate 5hydrate as catalyst with hydroxylamine HCl and sodium acetate or carbonate to basify the hydroxylamine. Reaction is solventless, run at 110C for 2hrs.
With sodium acetate, it boasts a 98% yield of amide, with sodium carbonate coming in at 88%. Certainly seems very promising, especially since they use a methylenedioxy benzene compound for the tests.
Hey Guys,
I want to see if theres a way to skip the relatively messy aldehyde to amide steps we see in the commonly accepted method.
One of the two papers details a reaction that converts piperonal to methylenedioxybenzamide using copper sulfate 5hydrate as catalyst with hydroxylamine HCl and sodium acetate or carbonate to basify the hydroxylamine. Reaction is solventless, run at 110C for 2hrs.
With sodium acetate, it boasts a 98% yield of amide, with sodium carbonate coming in at 88%. Certainly seems very promising, especially since they use a methylenedioxy benzene compound for the tests.
Will have a look into this when I have some free time!
Great work!
theres a 'one pot' to the amide using zinc nitrate hexahydrate. i dont have the paper but its worth reading that if it can be found if someones wanting to tweak the copper sulfate.
theres a 'one pot' to the amide using zinc nitrate hexahydrate. i dont have the paper but its worth reading that if it can be found if someones wanting to tweak the copper sulfate.