Requested by Sydenhams chorea
Pyrrylphenylethanones related to cathinone and lefetamine: synthesis and pharmacological activities.
Massa, S.; Di Santo, R.; Mai, A.; Artico, M.; Pantaleoni, G. C.; Giorgi, R.; Coppolino, M. F.
Archiv der Pharmazie
1992, 325(7):403-407
DOI: 10.1002/ardp.19923250707
Abstract
The synthesis of various pyrrylphenylethanones resembling cathinone and lefetamine is described starting from 2-chloro-1-(1-methyl-1H-pyrrol-2-yl)-2-phenylethan-1-one. Some derivatives showed good antinociceptic activity, comparable to that of morphine. The neuropsychopharmacological profile of title compounds has been also studied to explore their action on C.N.S.
Pyrrylphenylethanones related to cathinone and lefetamine: synthesis and pharmacological activities.
Massa, S.; Di Santo, R.; Mai, A.; Artico, M.; Pantaleoni, G. C.; Giorgi, R.; Coppolino, M. F.
Archiv der Pharmazie
1992, 325(7):403-407
DOI: 10.1002/ardp.19923250707
Abstract
The synthesis of various pyrrylphenylethanones resembling cathinone and lefetamine is described starting from 2-chloro-1-(1-methyl-1H-pyrrol-2-yl)-2-phenylethan-1-one. Some derivatives showed good antinociceptic activity, comparable to that of morphine. The neuropsychopharmacological profile of title compounds has been also studied to explore their action on C.N.S.