Requested by no1uno



Psychopharmacological studies of some 1-(chlorophenyl)-2-aminopropanes I. Effects on appetitive-controlled behavior
John E. Owen Jr
J. Pharm. Sciences
Vol.52(7) 1963, pp.679-683
DOI: 10.1002/jps.2600520716

Abstract

A series of 1-phenyl-2-aminopropanes with chloro substitutions on the 2, 4, 3, 4, and 4 positions on the phenyl ring and their optical isomers were compared with dl-and d-amphetamine and methamphetamine on a fixed-ratio (FR) procedure. The subjects were rats that had been trained to press a lever 30 times for 0.25-ml. reinforcement of sweetened condensed milk. Each session consisted of 40 reinforcements. With unsubstituted amphetamines, rats showed a slight reduction in response rates with long pauses following reinforcement. This effect was similar to the effect seen with onset of normal satiation. After chloro compounds, the rats produced irregular and slowed response rates with frequent short pauses between and following reinforcement. The minimum effective doses of all compounds used in this study ranged from 1–3.2 mg./Kg. Except for d-1-(4-chlorophenyl)-2-aminopropane, the l-isomers of chloro-substituted compounds were more active suppressants of FR behavior than the dl or d compounds.[/color]



Psychopharmacological studies of some 1-(chlorophenyl)-2-aminopropanes II. Effects on avoidance and discrimination behavior
John E. Owen Jr.
J. Pharm. Sciences
Vol.52(7) 1963, pp.684-688.
DOI: 10.1002/jps.2600520717

Abstract

A series of 1-(chlorophenyl)-2-aminopropanes previously shown to suppress appetitive-controlled behavior were compared with d-amphetamine and methamphetamine on an avoidance procedure. Rats trained to press a lever to avoid intermittent electroshocks were used. In alternate 10-minute periods, a rat received a time-out (TO) when no responding on the lever was necessary. The discrimination between the two periods was cued by appropriate visual stimuli. The two lowest doses that suppressed the appetitive-controlled behavior were studied. With the unsubstituted amphetamines, the rats produced high response rates during both the avoidance and TO periods with a reduction in the number of shocks received. On the whole, the chloro-substituted compounds produced relatively small increases in the rats' response rates with little or no change in the number of shocks received. These results indicate that, at the doses used, the chloro-substituted compounds produced less CNS stimulation than did d-amphetamine or methamphetamine.

Requested by RoidRage


Simple Method for the Esterification of Carboxylic Acids
B. Neises, W. Steglich
Angew. Chem. Int. Ed.
1978, 17, 522-524
DOI: 10.1002/anie.197805221

Requested by no1uno



Asymmetric organic synthesis. Preparation and birch reduction-alkylation of 2-methyl-3,4-dihydroisoquinolin-1-ones
Arthur G Schultz, Steven J Kirincich & Rainer Rahm
Tetrahedron Letters
Vol.36(26) 1995 pp.4551-4554.


Abstract

Birch reductions of 2-methyl-3,4-dihydroisoquinolin-1-ones 1 and 6 generate enolates 2a and 2b and alkylations provide 1,4-cyclohexadienes 3a–3e and 7a–7c. The synthesis of a racemic structural analogue, 9, of the potent analgetic levorphanol is described.[/color]




Oxy-morphinane. (4. Mitteilung). Synthese von Benzyl-octahydro-isochinolinen
O. Schnider & J. Hellerbach
Helv. Chim. Acta
Vol.34(7) 1951 pp.2218-2222
DOI: 10.1002/hlca.19510340716

Abstract

Birch reductions of 2-methyl-3,4-dihydroisoquinolin-1-ones 1 and 6 generate enolates 2a and 2b and alkylations provide 1,4-cyclohexadienes 3a–3e and 7a–7c. The synthesis of a racemic structural analogue, 9, of the potent analgetic levorphanol is described.[/color]


Commentary by requestee
One I'm pretty sure I had, but have lost over time, the other is the initial paper where they N-formylate the intermediate prior to the reduction step, avoiding having to try and mono-methylate the nitrogen.

Requested by coincoin



Sonochemical Activation of Al/Ni Hydrogenation Catalyst
Jana Dulle1, Silke Nemeth
Advanced Functional Materials
Volume 22, Issue 15, pages 3128–3135, August 7, 2012
DOI: 10.1002/adfm.201200437



Abstract
This paper proposes a sonochemical approach to the nanostructuring of Al/Ni catalyst with high content of accessible Ni centers and a high reusability. The surface and bulk composition as well as pore size distribution of this catalyst are controlled synergistically by adjusting the ultrasound intensity in aqueous solution. Sonochemical activation of Al/Ni alloy leads to formation of mesoporous Al/Ni metallic based frameworks with surface area up to 125 m2 g?1, and regular distribution of nickel active center in the porous matrix. One of the opportunities of porous Al/Ni catalyst is that due to a time-resolved controllable formation of protective oxide layer it can be stored and handled under air in comparison to traditional Raney catalysts which need inert conditions. The Al/Ni catalyst is characterized by scanning electron microscopy (SEM), electron diffraction spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), confocal scanning fluorescence microscopy (CSFM), solid-state NMR experiments, and powder X-ray diffraction analysis (PXRD). The catalytic activity was investigated for the hydrogenation of acetophenone

Requested by no1uno



A New Method for Synthesis of Manganese(III) Acetate Dihydrate
Turgut Gunduz, Necla Gunduz & Iffet Sakiyan
Synthesis & Reactivity in Inorganic & Metal Organic Chemistry
Vol.24(4) 1994 pp.519-524.


Abstract

A new method is reported for the synthesis of manganese(III) acetate dihydrate from manganese(II) acetate tetrahydrate, lead(IV) oxide and acetic acid as solvent. Melting point, mixed melting point with manganese(III) acetate dihydrate obtained by the well–known Christiensen method, elemental analyses, and potentiometric titration with a standard hydroquinone solution in acetic acid showed that the compound obtained by the new method was very pure (99.6%). In addition a solution of the compound in acetic acid was used to titrate potentiometrically some hydrazine derivatives and excellent results were obtained.






Oxidation by Cobalt(III) Acetate. Part 12. Stereoselective Formation of threo-1-Phenylpropane-1,2-diol monoacetate in Oxidation of ß-Methylstyrenes Unsubstituted and substituted with Electron-donating groups by Cobalt(III) and Manganese(III) Acetate in Acetic acid
Masao Hirano, Takayoshi Hamaguchi, Xiumin Zhang & Takashi Morimoto
J. Chem. Soc., Perkin Trans. 2
1989, pp.2141-2145
DOI: 10.1039/P29890002141

Abstract

Stereochemistry in oxidation of P-methylstyrenes unsubstituted and substituted with electron-donating groups (H, p-MeO, and p-Me) by cobalt(iii) and manganese(ii1) acetate in acetic acid or in acetic acid containing trifluoroacetic acid has been studied. threo-I -Arylpropane-I ,2-diol monoacetates were the main products in the oxidations of both E- and Z-alkenes by these oxidants. These results are explained in terms of the difference in stabilities between intermediate (11) and (14).