Cyrax
(Hive Bee)
01-26-02 08:33
No 261121
      3-methylfentanyl  Bookmark   

What is the chemical structure of 3-methylfentanyl?  Can someone draw me a structure formule?

Thx
 
 
 
 
    altair
(Hive Bee)
01-26-02 10:38
No 261154
      Re: 3-methylfentanyl  Bookmark   

EtCo   Ph
    \ /
     N
Me  |  
  \/   \
   |   |
   \   /
     N
     |
     \
      |
     Ph

something like this perhaps?

btw
this was then what now
 
 
 
 
    slappy
(Hive Bee)
01-26-02 19:17
No 261361
      Re: 3-methylfentanyl  Bookmark   

That is correct. It should also be noted that only (-)-cis-3-Methylfentanyl holds the extreme potency. Fentanyl is achiral, when you introduce that methyl group, you end up with 4 enantiomers.
 
 
 
 
    Cyrax
(Hive Bee)
01-27-02 04:20
No 261472
      Re: 3-methylfentanyl  Bookmark   

Isn't it amazing that 3-methylfentanyl is 30 times more potent than fentanyl ?

What about an enamine alkylation a la Stork to make the
3-methyl-4-piperidone?

Does anyone has refs. about the synthesis of 4-piperidone?
 
 
 
 
    slappy
(Hive Bee)
01-27-02 08:10
No 261509
      Re: 3-methylfentanyl  Bookmark   

Let me put it this way...

Attempted synthesis of 3-Methylfentanyl without a glovebox == Death