(Stranger)
05-26-03 16:36
No 435621
Is there an easy way to remove tetrabutylammoniumfluoride (TBAF) or other TBA-salts from your rxn-product, in cases where recrystallisation won´t work (other than ion-exchange chromatography)??
This TBA-stuff sticks to my product all the way through extracting, washing, and more than one flash-silicagel-chromatography!
(Moderator)
05-26-03 21:41
No 435675
Which product?
(I'm Yust a Typo)
05-26-03 22:09
No 435686
distillation?
(Stranger)
05-26-03 22:55
No 435699
products = different 1,2-Biphenylacetylenes from two succeesing Sonogashira-rxn with TMS-Acetylen and aromatic iodides
TBAF was used for removal of TMS-Group after first Sonogashira-rxn(destillation seems unprobable, products are crystalline solids)
(Hive Addict)
06-20-03 00:02
No 441134
Silica gel should remove it. Use the good 200mesh merck stuff. If that doesn't work, (I couldn't tell you why not)
use cation exchange resin.