(Stranger)
09-23-02 21:14
No 359793
"Ephedrine from Benzaldehyde and D-L Alanine, Heat to yield CO2 + ephedrine."
Does this really work? Will pure l-isomer alanine work as well? Is it just the benzaldehyde and alanine in equimolar ratio or some other ratio? No solvent mentioned, so none needed, I suppose?
Thanks Hive gurus!
ub
(Hive Bee)
09-23-02 23:38
No 359843
Hi!
I think you are confusing PPA and eph. By using the alanine + BA one will get PPA and not eph. To get eph you would have to use N-methyl-alanine, which is not so easy to come by as alanine.
As for solvent i belive you can find the answer by UTFSE.
Regards
Bandil
(Stranger)
09-24-02 15:22
No 360089
PPA, gotcha. I will FS for the solvent info U'ing TE.
(Hive Bee)
09-27-02 21:52
No 361506
use toluene or xylene as the solvent (although aurelius believes one may not be absolutely necessary- may even raise yeild) if picking between the two above, choose xylene, it has a higher boiling point (all three isomers are higher than toluene) and this allows for a better high boiling solvent for the decarboxylation that occurs at elevated temps.