(Hive Bee)
08-02-00 02:27
No 35584
This isn't really kitchen chem compatable, but I'm wondering about flourination of desirable compounds, yeilding things like DO(triflouromethyl),
2C-(triflouromethyl), and 3,5 dimethoxy 4- triflouromethyl phenethylamine and phenisopropyl amine.
for 2C-TF would one could a vilsmeyer rxn be performed on 2,5 dimethoxy 1 TFM benzene? Or would the TFM group be too electron withdrawing. Or perhaps start with 2 TFM hydroquinone in a basic solution, and do an ortho formylation, then methylate. I've only seen two halogenation reactions, replacement of halogen by KF/ 18- Crown-6 ether, and replacement of a diazonium salt by flouboric acid. Neither of those seem very applicable. Any help or even interest in this topic?
try www.flourosolutions.com and ask the from a business account.
alphabeta121
(Hive Bee)
08-03-00 06:59
No 36066
have the hive's world famous geniuses all died?
(Chief Bee)
08-03-00 22:38
No 36296
I have tried a knoevenagel reaction with trifluoromethylbenzaldehyde. The yield was dismal in several attempts, and the starting aldehyde very expensive.
http://rhodium.lycaeum.org
(Hive Bee)
08-04-00 05:46
No 36409
boner, so I guess that leaves a substituted acetonitrile reduction ala G_Pig? Sounds alright to me, but its the synthesis of the aldehyde that I'm interested in.