Rhodium
(Chief Bee)
11-12-02 15:31
No 379066
       Bromosafrole -> MDP2P  Bookmark   

This article on how to prepare MDP2P from Bromosafrole was posted by lugh a long time ago, but nobody seemed to grasp its significance. The yield is up to 90%, and the needed reagent is 2-nitropropane, which is not watched and also dirt cheap ($15/kg).

[image]

https://www.rhodium.ws/chemistry/halide.carbonyl.html 		 
 
 
 
    hest
(Hive Adickt)
11-12-02 15:51
No 379075
       2-nitro-propen  Bookmark   

But bee aware that 2-nitropropan is extremly carcinogenic.
  
 
 
 
    Rhodium
(Chief Bee)
11-12-02 16:07
No 379078
       2-nitropropene should neither be an impurity in ...  Bookmark   

2-nitropropene should neither be an impurity in the starting material or a product in the reaction. Do you have a different opinion? 		 
 
 
 
    Barium
(Hive Bee)
11-12-02 16:07
No 379081
       But Rhodium is talking about 2-nitroprop a ne, ...  Bookmark   

But Rhodium is talking about 2-nitropropane, not 2-nitropropene.
Catalytic hydrogenation freak 		 
 
 
 
    hest
(Hive Adickt)
11-12-02 17:30
No 379103
       nitropropan  Bookmark   

It was just ment as a general warning. Nito- methane, ethane and propane is almost non toxic, but 2-nitropropan is for some reason werry caracinogenic. So you have to doo the condensation with the aldehyde with much more care than usual, that's all. Nice synth by the way.