Rhodium (Chief Bee) 10-18-03 10:42 No 414904				Hydroamination routes to Amphetamines & PEAs	Bookmark
						Review: Base-Catalyzed Hydroamination of Olefins: An Environmentally Friendly Route to Amines Advanced Synthesis & Catalysis, 344(8), 795-813 (2002) (https://www.rhodium.ws/pdf/base-cat.hydroamination.review.pdf) DOI:10.1002/1615-4169(200209)344:8<795::AID-ADSC795>3.0.CO;2-Q A Base-Catalyzed Domino-Isomerization–Hydroamination Reaction – New Synthetic Route to Amphetamines DOI:10.1016/S0040-4020(00)00436-1 Tetrahedron 56(29), 5157-5162 (2000) (https://www.rhodium.ws/pdf/hydroamination.allylbenzene2amphetamines.pdf) [image] Post 271694 (foxy2: "Re: here it is: direct amination of allylbenzene", Chemistry Discourse) Post 465442 (Rhodium: "Hydroamination Route to Amphetamines", Chemistry Discourse) Amphetamines and phenyl-2-propanones from 1-phenylpropyne and amines Chem. Soc. Rev., 2003, 32, 104–114 (https://www.rhodium.ws/pdf/catalytic.hydroamination.alkynes.pdf) [image] Hydroamination of Cinnamylalcohol (http://www.unibas.ch/mdpi/ecsoc-3/a0025/a0025.htm) [image] Photoinduced amination of styrenes to phtalimide-protected phenethylamines Post 429395 (Rhodium: "Photophtalimidation of styrenes to PEAs", Serious Chemistry) [image] An Ammonia Equivalent for the Dimethyltitanocene-Catalyzed Intermolecular Hydroamination of Alkynes Post 434626 (ChemisTris: "Dimethyltitanocene cat. hydroamination of alkynes", Novel Discourse) Org. Lett. 2(13), 1935-1937 (2000) (https://www.rhodium.ws/pdf/dimethyltitanocene-hydroamination.pdf) DOI:10.1021/ol006011e [image] Synthesis of allylic amines through the palladium-catalyzed hydroamination of allenes Tetrahedron Letters 36(22), 3857-3860 (1995) (https://www.rhodium.ws/pdf/hydroamination.allenes.pdf) DOI:10.1016/0040-4039(95)00656-W [image] Riken Review No. 42, pp 53-56 (2001) (https://www.rhodium.ws/pdf/ruthenium.hydroamination.1-alkynes.pdf) Ruthenium complexes that efficiently catalyze hydration and hydroamination of 1-alkynes have been found. The hydration described here is the first example of anti-Markovnikov regioselectivity to produce aldehydes. A mechanism involving Ru(IV)-hydride-vinylidene intermediate is proposed. A highly practical catalytic hydroamination method has also been developed which was applied to synthesis of nitrogen containing heterocycles.