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	Posts 1 - 18 of 18	Subject: P2P



obituary (Hive Addict) 08-16-01 14:50 No 205221	P2P	Bookmark Reply
	Does anybody know the yeild for this procedure?Method with Benzyl Chloride Benzyl chloride (PhCH2Cl) and sodium give benzyl sodium. This reacted with ethyl acetate gives phenylacetone. No yield is given in the abstract. Tsuruta, Bull. Inst. Chem. Research, Kyoto Univ., vol. 31, 190-200 (1953) (in English); Chemical Abstracts vol 49, 6183b



Rhodium (Chief Bee) 08-16-01 16:30 No 205260	Re: P2P	Bookmark Reply
	Isn't this discussed in the meth forum? And isn't this method described in one of fester's books? If so, where?



WizardX (Wizard Master) 08-16-01 19:43 No 205312	Re: P2P	Bookmark Reply
	This is WHY benzylchloride is so highly restricted. benzylMgCl + acetic anhydride ==>> P2P -78oC benzylNa + CH3COCl(acetyl chloride) ==>> P2P 95+% (benzyl)2Zn + 2 CH3COCl(acetyl chloride)==>> 2 P2P + ZnCl2 benzylMgCl + CH3CH=N-CH3 ==H2O==>> Amphetamine



terbium (Hive Addict) 08-16-01 20:10 No 205318	Re: P2P	Bookmark Reply
	Really, benzyl chloride is restricted? Even so, I'll bet that benzyl alcohol isn't. A little muriatic acid should serve to convert the alcohol to the chloride.



Rhodium (Chief Bee) 08-16-01 23:55 No 205368	Re: P2P	Bookmark Reply
	Wizard: What are the refs for those P2P production schemes?



WizardX (Wizard Master) 08-18-01 22:25 No 205777	Re: P2P	Bookmark Reply
	Will put the refs together.



tecnetium (Hive Bee) 08-20-01 20:18 No 206192	Re: P2P	Bookmark Reply
	R- Maybe you could put those synths on your page....Please please please. PS- Benzyl chloride is easily made from BZOH HCL and a little ZnCl2



Lino (Hive Bee) 09-06-01 18:17 No 210926	Re: P2P	Bookmark Reply
	If someBee had a couple a litres of BzCl, but was sick of failed Grignards; he couldn't buy the acetic anhydride. Is there any way the BzCl could be rearranged/reduced… whatever to the aldehyde. SomeBee saw a post by anomolon which claimed benzAl chloride (AKA a,a-dichlorotoluene) could be boiled in alkaline water, to make benzaldehyde (?). That doesn't seem to work w/ BzCl though. If converting benzAl chloride to benzaldehyde is so simple… I noticed they list a 3,4-dichlorotoluene: I was wondering… Linoleum: the 13th element! Now available at all good DIY stores… & Walmart.



obituary (Hive Addict) 09-06-01 21:29 No 210969	Re: P2P	Bookmark Reply
	if you use Benzalchloride (dichloromethylbenzene) and boil it with a basic solution the OH will replace both of the halogens to give a dihydroxy-compound (geminal-diol) that will automatically dehydrate (lose water) to give the benzaldehyde this will work for various sub'd benzaldehydes



Alkylight (Newbee) 09-06-01 22:54 No 210988	Re: P2P	Bookmark Reply
	Can't benzylchloride just be treated with hydroxide and then oxidised with say KMnO4 or the likes (but don't go too far-then you get benzoic acid-which can be then converted to P2P with sodium acetate and acetic anhydride???



terbium (Hive Addict) 09-06-01 23:13 No 211000	Re: P2P	Bookmark Reply
	then you get benzoic acid-which can be then converted to P2P with sodium acetate and acetic anhydride??? Really! You have discovered some new chemistry here.



Rhodium (Chief Bee) 09-07-01 03:24 No 211047	Re: P2P	Bookmark Reply
	Lino: Reaction of benzyl chloride with hexamethylenetetramine followed by hydrolysis yields benzaldehyde. It is a name reaction, but I have forgotten the name of it. Alkylight: Benzoic acid won't react that way, but phenylacetic acid will. That's why phenylacetic acid is controlled, but not benzoic acid (which can even be had as the sodium salt in grocery stores as a preservative).



obituary (Hive Addict) 09-07-01 20:43 No 211268	Re: P2P	Bookmark Reply
	Rhodium, thanks for the tip on the benzald. synth do you have any idea what the general pathway is for that rxn? perhaps a key word to search to find info on that specific rxn?



terbium (Hive Addict) 09-07-01 22:59 No 211291	Re: P2P	Bookmark Reply
	Lino: Reaction of benzyl chloride with hexamethylenetetramine followed by hydrolysis yields benzaldehyde. It is a name reaction, but I have forgotten the name of it. Sommelet reaction.



obituary (Hive Addict) 09-08-01 16:57 No 211494	Re: P2P	Bookmark Reply
	thanks Terbium



tecnetium (Hive Bee) 09-08-01 19:43 No 211523	Re: P2P	Bookmark Reply
	Hey Lino Have you considered making your own Ac2O? It can be made form Br, S and sodium acetate (made form acetic acid and sodium hydroxide)- check out the synth at Rhodiums page. Also: I recall a grignard reaction that was discussed that made P2P from BzMgCl and acetonitrile but I can not seem to find any of the old threads- can anyone please give me the reaction details.



jim (Hive Bee) 09-08-01 21:42 No 211547	Re: P2P	Bookmark Reply
	An even better way to Ac2O is from acetone via the ketene degradation, see rhodium's website for the link.



Lino (Hive Bee) 09-13-01 19:23 No 213294	Re: P2P	Bookmark Reply
	Rh. & terbium: cheers! Vogel's 5th p999-1002. SomeBee sez she's got hexamine and GAA in stock so will give it a go and pass on the results of course. Gimme a month or so as SomeBees goin' to Ibiza!!! Lucky Bee. tecnetium: didn't fancy all the messin' & coughin' w/Br2. I could buy the fff…sucker but it attracts attention due mostly to it's use in synth of H. Apparently one has to sign End User Cert. Re. MeCn… bin' there, done that, etc, etc. It doesn't run, not for SomeBee anyhow. Poodle did a 'Right' Up of it (poss on Rh's pg.) but alas Poodles broken English was not clear enough to follow for crucial bits. Sorry Poodle, I'm sure your English is X100 better than Lino's French. jim: regarding Ac20 from keten. Vogel shows us the device and how to do it on p101. Arthur also mentions in a note "Keten is a poisonous gas having a toxicity comparable with phosgene". Now: for you younger Bees who don't remember WW1. Phosgene was used by the Germans before they invented mustard gas and… Errrrrr… does any Bee have experience of 3,4-dichlorotoluene or a,a-dichlorotoluene? Linoleum: the 13th element! Now available at all good DIY stores… & Walmart.

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