Amphetamine synthesis for a beginner

loki · guinea pig

well, if one has one's heart set on the non-methylated one, just substitute ephedrine for phenylpropanolamine. not so easy to get. quite frankly i don't get what the allure of amphetamine is, when i take it i feel like something is squeezing my upper chest and throat tight and it hangs on for hours, and while i am able to sleep the night i take it the sleep is much lighter than normal.

if its any consolation, the body naturally de-methylates methedrine with the enzyme CYP2D6. you can get more of the amphetamine type effect by taking milk thistle which encourages production of this enzyme (it is also responsible for removing that pesky methyl group from codeine thus liberating morphine, which is actually how codeine achieves its analgesia). Another thing which will improve this is ensuring that the product of the reaction contains no iodephedrine, because this chemical is a CYP2D6 inhibitor. This can be avoided by ensuring that this is fully reduced, the hypophosphorous reaction does this, and so does the LWR, but a traditional hot/dry fast cook often produces nontrivial amounts of it in the end product.

i think the reason why i prefer the methylated amphetamine is because it has stronger sympathomimetic effects, which have the exact opposite effect on the respiratory system (adrenalin in the lungs opens everything up). i'm not sure what this is caused by exactly, something to do with its selectivity for binding with adrenalin receptor sites means it gets a more even alpha and beta adrenergic effect rather than too much alpha and zero beta (beta adrenergic stimulation results in deeper breathing, faster pulse and dialates the blood vessels in the lungs i think). The key signature of this different type of sympathomimetic effect is the pupillary dilation, which is identical to what one gets from an injection of adrenalin or direct application of adrenalin to the eyes. amphetamine does not cause pupillary dilation.

it is in a large part related to adrenergic stimulation that both ---- and cocaine have the euphoric effects, gives that all-over warm feeling etc. ---- gives it the best and most safely imo, cocaine has too much cardioacceleration (one of the beta adrenergic receptors controls this) which in combination with vasoconstriction can produce cardiac arrest. I guess it probably would be valid to describe ---- as being like a midpoint between cocaine and amphetamine in this respect.

i'm not completely clear on this subject really, all i know is that the sympathomimetic effects of methedrine are much more pleasant. in fact, the peripheral effects of amphetamine meant i was unable to use it at all, and as a result i have been unable to actually medicate for my ADD, ritalin sent me crazy and aggro, dex made me anxious and brought on asthma and made me feel overall more tired than before i was taking it. extremely frustrating to learn this at the time that there is this unheralded and unscientific discarding of the medical utility of methedrine.

Sway · Sat Sep 17, 2005 11:20 pm

CYP2D6 enzyme de-methylates methedrine? Interesting. By chance, would you have a link to a list or table of some sort that classifies various liver enzymes, and describes their typical effects on various molecules? Thanks.

loki · guinea pig

no, i don't unfortunately. the information source for this was the internet, a friend of mine who is constantly reading studies etc is always digging up neat new bits of info.

CYP2D6 is actually an oxidase enzyme whose job is to help decompose stray drug molecules. hehe

loki · guinea pig

i am quite amazed that the initator of this thread didn't see the rhodium archive at the root of this webserver.

joe_aldehyde · huxleys associate

well, lets say, he's just a lazy f**** expecting to have all the preliminary work done for him.