phenylpropanolamine from benzaldehyde

Stinger · Thu May 05, 2005 9:31 am

It seems as a base catalyst would be needed in order to avoid biphenyl compnd. formation and favor phenylpropanolamine production..

I wonder if the short reaction time plays a part in the success of reaction 3, and the failure of reaction 2, to obtain PPA?

java · Consumer

One would need to translate the articles and study them in order to make some comments on the reaction since they did 3 other papers prior to the one's I posted.

There needs to be someone with some japanese to english translating program....so we can all find out.....java

IndoleAmine · Dreamreader Deluxe

Without any knowledge in japanese: reactions 2 and 3 both run 40 minutes - only difference is pyridine... Very Happy

But it would indeed be really very helpful if someone could translate those cryptic signs...

java · Consumer

This is another study in the series of benzaldehyde and amino acids reactions for which there is a whole series that need translating......java

Studies and Reactions between Aromatic Aldehydes and alpha-amino Acids I. New Facts on Akabori Reaction
Takagi; Yakugaku Zasshi;]
The Pharmaceutical Society of Japan Study #185,vol. 71, no. 7, pg 648, 1951

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Note : thanks to Lugh for securing the citation