feasible new route to p2ps?

[acid_egg]

I found this brief reference hinting at another route to p2ps.Could it also be useful for ring substituted p2ps too?Is it feasible or useful and if so can someone with access post it plz?

"...Tri-n-butyl tin methoxide reacts with isopropenyl acetate to give,in situ acetonyl tri-n-butyltin which undergoes a Pd catalysed coupling reaction with aryl bromides[bromobenzene] to give aryl acetones[phenyl-2-propanone]...."

                 n-Bu₃SnOMe                          ArBr,PdCl2,P(o-tol)₃
AcOCH(CH2)CH3   -------------->    n-Bu₃SnCH2COCH3   -------------->   ArCH2COCH3

ref:Chem. Lett.,939 (1982)

Parts in red I have added.

[Rhodium]

What's your price for the Bu₃SnOMe? I see Acros carry it for $30/25g (with "Toxic" and "Envirotoxin" ratings), and considering that the molar weight is 321 g/mole, it is costly to employ it in stoichiometric amounts.

The Pd complex is just used as a catalyst.

[acid_egg]

it is costly to employ it in stoichiometric amounts

Ah..of course..thats the kicker!

I think it was listed in mine at ~$75/100g.
That envirotoxin bit sounds about right as I believe its used as 'defoulant' for boats.(for barnacles and such I suppose.)

[josef_k]

You can also use isopropenyl acetate to make p2p from an aniline via the diazotonium. I'm not so sure if it works without an electron withdrawing group on the ring though. The patent I saw it in made 3-trifluoromethyl-p2p. If anyone is interested it is

Patent US5811586

. Nevertheless it would be interesting to make the 4-tfm-amph.