Conformationally Restricted Fentanyl Analogs

[pHarmacist]

Bioorganic & Medicinal Chemistry Letters, Volume 5, Issue 11, 8 June 1995, Pages 1177-1182

Linas V. Kudzma, Suzanne M. Evans, Stanhope P. Turnbull, Jr. , Sherry A. Severnak and Edward F. Ezell

Abstract: Synthesis, analgesic activity and preliminary molecular modeling studies of the cis- and trans-fused octahydro-1,2,3,4,4a,5,11,11a-pyrido[3,4-c][1,5]benzoxazepines8 and 9, the first rigid fentanyl analogs with a conformationally restricted 4-anilido group that retain antinociceptive properties, are reported.

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