18-methoxycoronaridine (18-MC)

[MistaMiyagi]

Just got my issue of Discover today... interesting popular-language overview of ibogaine and its cogener, 18-methoxycoronaridine.

18-MC, according to the article, presents some of the addiction-quelling properties of ibogaine without ibogaine's side effects.  Don't know if this would be of use to anyone... I am still teaching myself o-chem and thought someone may wish to try and synth/taste/research this.  A WebCrawl for 18-methoxycoronaridine found this blurb:

...18-methoxycoronaridine exerts its anti-addictive effects via a reversal of the neuroadapations mediating increased incentive salience for drugs of abuse...

  Maybe in addition to its apparent anti-addiction potential, could it be used by hedonists (read: people like me) to resensitize the CNS to 5-HT-ergic and DA-ergic (read: almost any enjoyable) drugs?

The article:
Abrams, Michael.  "The End Of Craving."  Discover May 2003 (vol. 24 : no. 5) pgs 24-5.

Page of citations of 18-MC research:

http://www.ibogaine.org/18-mc/

[Rhodium]

Ibogaine is pretty much unsynthesizable, I have only seen one preparation of it in the literature, and that one comprised 35 steps or something in total...

[pHarmacist]

A Comprehensive Literature Review to bee found at:

http://userpages.umbc.edu/~jfreed1/Ibogaine.html

Here is it in PDF format:

http://userpages.umbc.edu/~jfreed1/Ibogaine.pdf

[pHarmacist]

This makes me wonder if not 2C-I should be classified as an oneirogenic material?

[yellium]

Yup, I've noticed this on 2C-I too. Depends a lot on setting. Other materials (2C-E) have this property too.