Author Topic: I want to make it bigger.  (Read 3995 times)

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apis

  • Guest
I want to make it bigger.
« on: June 06, 2000, 07:04:00 PM »
O Thou, mighty elephant headed god of experience, clearer of obstacles and beneficent guide of the ignorant and cocky:  What do I need to know to safely and productively upscale a reaction of this nature (say, 300x) ?

Would this reaction work with acetone  instead of formaldehyde to isopropylate an amine?

Tet. Lett. 3, 261 1973. B. L. Sondengam

Formaline (35%, 35 mmol) was added with stirring to a solution of holafébrine
(prim. amine) 3 mmol in methanol (10 ml) and the solution was refluxed for
30 min. After cooling 400 mg NaBH4 was added slowly. After 1 h the reaction was
evaporated and the mixture was extracted with CHCl2. Evaporation yields iréhine
(dimethyl-holafébrine, 85%).


I bow down to your exquisitely manicured toenails in advance.  thankyou


Rhodium

  • Guest
Re: I want to make it bigger.
« Reply #1 on: June 06, 2000, 07:20:00 PM »
1) First, try it out on a 5-10 gram scale to see if it works satisfactorily.

2) The only things I can think of with the scaling is that you probably do not need to scale the solvent 300x, try 150x and see if all the amine dissolves first. Also, you need good cooling, and make sure that the NaBH4 additions doesn't cause too much foaming/heat when you add it. You are scaling the heat evolution 300x, you know.

3) If it works satisfactorily on the tryptamine of your choice, please give a full report on your procedure and yield to me, and I'll upload it to my page.

http://rhodium.lycaeum.org


Vulpes

  • Guest
Re: I want to make it bigger.
« Reply #2 on: June 07, 2000, 11:33:00 AM »
Apis could you mail me at red_fox@hushmail...


Lilienthal

  • Guest
Re: I want to make it bigger.
« Reply #3 on: June 07, 2000, 12:55:00 PM »
Try it with < 50 mg. But the most important thing is: check the reaction by TLC if it takes the right way and how fast. Do not even think of starting this reaction without TLC equipment and reference substances. This type of reaction is not really tested with tryptamines. Tryptamines with formaldehyde cyclize under H+ catalysis into beta-carbolines (Pictet-Spengler-Reaction). Please post your results (positive as well as negative ones) since we are highly interested in that.


Rhodium

  • Guest
Re: I want to make it bigger.
« Reply #4 on: June 07, 2000, 01:20:00 PM »
I have a post from KrZ on my page where he makes DMT from tryptamine in moderate yields using NaBH3CN (and he even added some acetic acid to the mix)...

http://rhodium.lycaeum.org


ScuzZ

  • Guest
Re: I want to make it bigger.
« Reply #5 on: July 03, 2000, 06:13:00 AM »
Dude, in attempting this reaction. I give you one part of advice.

Whenever heating acetone make sure you heat it steadily and never let the temperature drop to dramatically otherwise you'll never have the arms to post another message.


Rhodium

  • Guest
Re: I want to make it bigger.
« Reply #6 on: July 04, 2000, 04:52:00 PM »
Scuzz: I don't agree with you on that, and this doesn't apply to the reaction above anyhow, as acetone is just a reagent, not a solvent (methanol is).

http://rhodium.lycaeum.org


ScuzZ

  • Guest
Re: I want to make it bigger.
« Reply #7 on: July 05, 2000, 07:27:00 PM »
You know what I mean dude. I was just a little wacked when I wrote it.


eli3

  • Guest
Re: I want to make it bigger.
« Reply #8 on: July 08, 2000, 04:55:00 AM »
yes,yes we "know what you mean"(wink,wink,nudge,nudge);know what you mean...


you mean, YOU DON'T KNOW A GOD DAMNED THING ABOUT CHEMISTRY.(or possibly anything else since you can't even lie worth a shit!)

Try again!

"pull the wool over your own eyes"

eli3

  • Guest
Re: I want to make it bigger.
« Reply #9 on: July 08, 2000, 05:03:00 AM »
oh yeah, now i remember, the old "acetone arm explodie trick"; thats a good one...

have you been trepanned?

"pull the wool over your own eyes"

eli3

  • Guest
Re: I want to make it bigger.
« Reply #10 on: July 08, 2000, 05:25:00 AM »
Rhodium, can you think of any drugs that lobotomize the user, leaving them unable to speak or write(think?) a word of rationale?


lode me up......i want to get "whacked out".

"pull the wool over your own eyes"

Rhodium

  • Guest
Re: I want to make it bigger.
« Reply #11 on: July 08, 2000, 12:02:00 PM »
eli3: No personal attacks in this forum. We have private messaging for that.

http://rhodium.lycaeum.org