Author Topic: the easiest way to AMT / AET / 5-MeO-AMT  (Read 2391 times)

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jesus

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the easiest way to AMT / AET / 5-MeO-AMT
« on: June 23, 2000, 02:06:00 PM »
One doesn't have to think hard if one had a look at the 'P2Pol from acetaldehyd' thread to come to the following thought:

Tryptamine or Tryptophan --> Indole-3-AcH

Indole-3-AcH   NH3 --> Indole-3-AcH-imine

Indole-3-AcH-imine -MeMgI-> AMT or -EtMgI-> AET

for 5-MeO-AMT one obviously has to start with 5-MeO-I3ACH.

So what do you think, could this work ??
/jesus



Rhodium

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Re: the easiest was to AMT / AET / 5-MeO-AMT
« Reply #1 on: June 23, 2000, 05:27:00 PM »
I believe the easiest way would be to formylate the indole to the indole-3-aldehyde, and then react it with nitroethane/nitropropane to get the nitroalkene, then reduce it with LAH or similar.

http://rhodium.lycaeum.org


psyloxy

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Re: the easiest was to AMT / AET / 5-MeO-AMT
« Reply #2 on: June 24, 2000, 04:09:00 AM »
Not everyone has easy access to Indole, POCl3, NMF, EtNO2/PrNO2 and LAH.

But would it still work even if it's not your favorite route ?

--psyloxy--





Rhodium

  • Guest
Re: the easiest was to AMT / AET / 5-MeO-AMT
« Reply #3 on: June 24, 2000, 05:12:00 AM »
The indoleacetaldehyde is very polymerization-prone, and I believe the imine would be too.

http://rhodium.lycaeum.org