Procedure for the Synthesis of Formyl Amides

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A New, Simple Procedure for the Synthesis of Formyl Amides

Lidia De Luca, Giampaolo Giacomelli,* Andrea Porcheddu, Margherita Salaris

Abstract: A simple and mild method for the N-formylation of amines and a-amino esters is described via reaction with 2-chloro- 4,6-dimethoxy[1,3,5]triazine and formic acid. The reaction can be accelerated under microwave irradiation and yields the N-formyl species in high yields and without racemization in the case of optically active a-amino esters.

SYNLETT 2004, No. x, pp 000A–000Cx.x.204

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Note:I think this can be used for the Monomethylation of amphetamines.