CuCl/CuCl2/I2 a-iodination of propanoic acid - 90%

[psyloxy]

https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000505628-chem_lett_1984_-_1509_1510.djvu" target="_blank" title="Download this file">

chem.lett. - 1984 - 1509/1510

alpha iodopropanoic acid (brief summary, read the 2 page .djvu!)

CuCl (0.5 mol equiv), CuCl₂ (0.5 mol equiv), I₂(1 mol equiv) and propanoic acid (excess) are mixed and reacted at 120°C for 6h under N₂ atmosphere. Precipitated copper salts are filtered, excess acid is distilled off, product is recrystallized from hexane to afford a 90% yield based on I₂.


where to go from here ?

Post 212002

(Rhodium: "Easy nitroethane in quantitative yield", Methods Discourse)

Post 333551

(Barium: "benzaldehydes to phenylacetones", Novel Discourse) w/the corresponding alkyl esters; prep. of methyl ester: J.Org.Chem.; 45; 14; 1980; 2831-2834.

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[moo]

Nice find!