Author Topic: Clorination of 2,5 dimethoxy toluene  (Read 1289 times)

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Vibrating_Lights

  • Guest
Clorination of 2,5 dimethoxy toluene
« on: March 11, 2003, 10:29:00 PM »
Can 2,5 dimethoxy toluene be chlorinated in the same manner as toluene normaly would.  Would the rest of the ring not bet chlorinated at the same time. 
A friend told me of a synth from benzyl chlorides where two moles of benzyl chloride would both attach to zinc.  The acetonitrile is added.  A reducton with NaBH4 gives PEA.  I am waiting to hear back from him for some refs.  But what about the chlorination???
VL_


Bandil

  • Guest
hmmm... I'd say yes. If you can chlorinate...
« Reply #1 on: March 12, 2003, 01:40:00 AM »
hmmm...

I'd say yes. If you can chlorinate toluene with hypochlorite, i cant see why i would not work on 2,5-dimethoxytoluene. The only site, that possibly could be attached would be the 4-position. It is quite activated on the dimethylether-compound, but the worst think that could happen is that it gets chlorinated :) In that case i guess you could just brominate instead and then you'r a step closer anyhow.