proscaline

[mysterious]

hi all friends!!

anyone every tried proscaline (p)?? i read of it in shulgins book!! do you know if this substance can be made of any uncontrolled substances??

anyone who tried it: how would  you describe the effects??

nice greetings!!
mysterious

[Barium]

Syringaldehyde is alkylated with propyl iodide to 3,5-dimethoxy-4-propoxybenzaldehyde, the benzaldehyde is reacted with a chloroacetic acid ester in a Darzens condensation to give (3,5-dimethoxy-4-propoxyphenyl)acetaldehyde. This acetaldehyde can be reductively aminated with ammonia and Raney nickel, or the aldoxime formed with hydroxylamine which is then reduced to the amine proscaline (3,5-dimethoxy-4-propoxyphenethylamine). All reagents here are pretty unwatched.

[Rhodium]

And syringaldehyde is easily made from vanillin:

https://www.thevespiary.org/rhodium/Rhodium/chemistry/mmda.mescaline.html

[Antoncho]

the benzaldehyde is reacted with a chloroacetic acid ester in a Darzens condensation to give (3,5-dimethoxy-4-propoxyphenyl)acetaldehyde. This acetaldehyde can be reductively aminated with ammonia and Raney nickel

Mmmmm, can you elaborate on that? Ever done this? I mean, you once wrote you were going to, but thus far all i read from you was on P2Ps via chloropropionates. Maybee, i should UTFSE better?

I always had a notion of this method as of somehow untrustworthy since those acetaldehydes would bee very hard to keep from polymerisation.... no?


Antoncho

[Rhodium]

See

Patent US5057624

.

[hypo]

> And syringaldehyde is easily made from vanillin:

iirc some bees (antoncho?) have had problems with the
methoxylation step.

uemura had big problems separating OH-vanillin from vanillin.
(ok, that's not syringaldehyde, but related)

i don't consider those syntheses "easy".
(for otc-bees. now if you have high grade chemicals it's probably a breeze...)