News:

Registration doesn't require a real email.
Monero Donation Address: 897ESh4QoJgEytJueBPULziMDfNMToXkGMrvtUCJRo2NQRv2CXACHnmEzeMTkwQhnfcZsAc3ctXp6GsedhMfBv983rn5i84

Main Menu

Impurity -> Grignard?

Started by Bwiti, December 16, 2002, 04:42:00 AM

Previous topic - Next topic

0 Members and 1 Guest are viewing this topic.

Bwiti

I dried my THF over NaOH for about a week, then decanted it off into a dry bottle with a teflon screw-cap. After doing this, I noticed that a small amount of NaOH particles came over with it. Will this adversely effect a Grignard rxn?

Love my country, fear my government.

Rhodium

As OH- is way more acidic than R-, any hydroxide ions in the THF will consume one equivalent of grignard reagent. I suggest that you distill it before use, or you might get problems starting the reaction (unless you are making MeMgI or any other very reactive grignard).

Bwiti

I'm planning on using bromobenzene, so I'll have to distill. Thanks for the heads-up. :)

Love my country, fear my government.