Preparation of D-Phenylalanine from DL-Phenylal...

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Preparation of D-Phenylalanine by Asymmetric Transformation

Chinese Chemical Letters Vol. 15, No. 4, pp 411-412, 2004

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Abstract

 The method of preparing D-phenylalanine by asymmetric transformation is reported.
D-phenylalanine was prepared from DL-phenylalanine by two-step reaction. D-phenylalanine (2S,
3S)-tartrate was prepared by heating DL-phenylalanine, salicylaldehyde, and (2S, 3S)-tartaric acid
in propionic acid; the obtained D-phenylalanine (2S, 3S)-tartrate was treated with triethylamine in
ethanol giving D-phenylalanine with 98% optical purity in 69% yield.

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