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One Pot Conversion of amino acids to alcohols..

Started by java, July 08, 2004, 11:54:00 AM

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A Convenient One-Pot conversion of N-Protected Amino Acids and Peptide into Alcohols
George Kokotos

Synthesis 4, 299, 1990

https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000518200-s-1990-26857.pdf" target="_blank" title="Download this file">



Abstract

N- Protected amino acids and peptides are converted to alcohols by chemoselective reduction of their corresponding mixed anhydrides with sodium borohydride in tetrehydrofuran with dropwise addition of methanol