catalyzed nucleophilic substitution of halosafrole

[claude]

Hi,

it seems that nucleophilic substitutions can be catalyzed by the used of chloride ion. It comes from it's excellent nucleophilic and nucleofuge properties (cf. comparative tables in books).

For exemple, with iodide catalyze, halide (bromo and chloro) alkyl can react with ammonia in a methanol solution to give the amine (after deprotonation of the ammonium).

So, it seems that this method could be applied in the formation of MDA from chloro or bromo safrole, with large excess of ammonia (to prevent the formation of secondary, tertiary,... amine), and without the use of a "pipe bomb".

What's your opinion concerning that ?

[chochu3]

You can catalyze the reaction of bromosafrole by using sodium iodide and adding NH3 or MeNH2.  This works if you have a halo component and you use an akali halide of the lower series on the periodic table.

[hest]

search for Finkelstein or look him up in March