Author Topic: J-CLANDEST-LAB-INVEST-CHEM-ASS  (Read 3592 times)

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Rhodium

  • Guest
(MD)MA without methylamine
« Reply #20 on: November 29, 2002, 05:56:00 PM »
Then of course is the possibility of making N-formyl-(MD)amphetamine using ammonium formate/(MD)P2P, and then reduce the amide to (MD)MA with NaBH4 plus a metal salt (ZrCl4, CoCl2, NiCl2, LiCl etc).

That way you can arrive at (MD)MA from (MD)P2P without the need for any methylamine, and the yields should be similar to that from the Al/Hg reductive amination.

flipper

  • Guest
so
« Reply #21 on: January 12, 2003, 09:53:00 PM »
When you use methylamonium formate and follow the procedure as in Antoncho's post you will not have a high yield of MDMA?????. Why not?

PolytheneSam

  • Guest
What happened to this?
« Reply #22 on: January 12, 2003, 10:21:00 PM »
What happened to this?
 

https://www.thevespiary.org/rhodium/Rhodium/archive/leuckart.pdf



Go to

http://briefcase.yahoo.com

, log in as everybee2, password = allbees and then go to

http://briefcase.yahoo.com/apis_mellifica2002


Look in the Leuckart Reaction folder. 
You need a TIFF browser plug in to view, ie. from

http://www.alternatiff.com




Organikum

  • Guest
this was what happened:
« Reply #23 on: January 12, 2003, 11:54:00 PM »

https://www.thevespiary.org/rhodium/Rhodium/pdf/leuckart.pdf



Rhodium reorganized his page a some weeks ago.

ORG


flipper

  • Guest
leukart
« Reply #24 on: January 15, 2003, 12:19:00 PM »

Leuckart Reaction
Methylamine is substituted in the Leuckart reaction for MDA to produce MDMA[57]. This is elaborated below. Uncle Fester[58] describes generating high purity N-methyl formamide[59] and then carefully reacting this with phenylacetone for highest yield of methamphetamine. Substituting piperonylacetone for phenylacetone would give MDMA. Fester gives long "idiot proof" directions so I refer you to his book for his directions.

To a three-necked flask equipped with a dropping funnel, thermometer (into the reaction mixture), and down directed condenser (simple distillation apparatus) is added with 133g (1.72 moles) of 40% methylamine solution and 88g (1.72 moles) of 90% formic acid. The temperature is raised to 160°C by distilling out water, and 59.4 grams (0.334 moles) of piperonylacetone is added at one time. The following apparatus can be substituted for a three-neck flask and the piperonylacetone added by momentarily replacing the thermometer with a funnel. The mixture is maintained at 160-170°C for 7 hours and any ketone which distills over is periodically returned to the flask. The formyl derivative is hydrolyzed in the reaction mixture by refluxing for eight hours with 120 ml of concentrated HCl (145ml 31.5% muriatic acid). The mixture is diluted with 200 ml of water and extracted with benzene (or ether etc.) to remove water insoluble material. The aqueous solution is treated with a little charcoal, Norit (or filtered through activated charcoal from pet stores). The solution is made alkaline with ammonia (or alternatively 25% NaOH) and the oil thus produced is extracted with benzene (or ether etc.). The benzene is washed three times with water and dried with sodium sulfate or other drying agent. A stream of HCl gas is fed through the solution until no more precipitate is formed. The precipitate is filtered out and allowed to dry.

40% methylamine is the commonly available form along with methylamine hydrochloride. Basifying 116g of methylamine hydrochloride with 68.5g of NaOH in 80 ml of water will approximate the 40% solution called for. Slowly add the methylamine hydrochloride to the NaOH solution after it cools. Keep the solution cool to maximize the solubility of the methylamine.

Substituting ethylamine will give Eve.




If it give a high yield of Meth wouldn't it also give a high yield of MDMA????????


GC_MS

  • Guest
*
« Reply #25 on: January 15, 2003, 02:41:00 PM »

If it give a high yield of Meth wouldn't it also give a high yield of MDMA????????




No, not necessarely. MDMA is Ph ring substituted.