cocaine from tropinone

[Grignard]

[Rhodium]

It was too hard to UTFSE, I suppose? The following thread is among the top 20 in this forum even:

Post 477883 (missing)

(Rhodium: "Practical Total Synthesis of Cocaine", Methods Discourse)

[Grignard]

yes a lot of references there, but i dont find an answer on how to make Methylecgonine from tropinone.. In this old text they reduce tropinone with raney Ni, Is this a process that will work and under what yield? it is this reference i would like to see...

[Rhodium]

The Findlay paper here converts tropinone to 2-carbomethoxytropinone:

Post 488336

(Rhodium: "Synthesis of Tropinone & 2-CMT", Methods Discourse)
And the links at the bottom of the page concerns the reduction of the latter to methylecgonine. The papers in

Post 487702 (missing)

(Rhodium: "Willstätter's Classic Cocaine Synthesis", Methods Discourse) also details the procedure.

[roger2003]

See:

Patent DE406215