Author Topic: Tri-alkyl silane / TFA reduction of aryl ketone  (Read 2399 times)

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Protium

  • Guest
Tri-alkyl silane / TFA reduction of aryl ketone
« on: September 04, 2001, 07:22:00 PM »
Well, this is my first post - and I'm here to ask if anyone has attempted the direct reduction of the benzyl -OH of pseudoephedrine to afford methamphetamine using Et3SiH / TFA ?

It's a rxn used to reduce aryl carbonyl groups back to the methylene, however, as it goes through the alcohol intermediate, you'd think this would work?  If no one writes back I'll try it out and post my write up.  Should go 99% or so according to the paper.  Not so bad, using 2.2 equiv. Et3SiH + 10-15 equiv TFA - stir.. rxn over in 15 mins..

off to the pharmacy.. 8)

Rhodium

  • Guest
Re: Tri-alkyl silane / TFA reduction of aryl ketone
« Reply #1 on: September 04, 2001, 07:42:00 PM »
I believe Dave Nichols used that method to reduce a cathinone to an amphetamine in the synthesis of the compound mentioned in the thread "New amphetamine more potent than LSD" in this forum...

Lilienthal

  • Guest
Re: Tri-alkyl silane / TFA reduction of aryl keton
« Reply #2 on: September 05, 2001, 12:25:00 AM »
NaBH4 / TFA should work also.

jim

  • Guest
Re: Tri-alkyl silane / TFA reduction of aryl keton
« Reply #3 on: September 05, 2001, 03:24:00 AM »
LiAlH4/ AlCl3 in ether works to reduce benzyl alcohols. REFERENCE:"The Journal of Organic Chemistry", Vol 29, yr 1964, page 110-115

akata

  • Guest
Re: Tri-alkyl silane / TFA reduction of aryl ketone
« Reply #4 on: September 05, 2001, 03:02:00 PM »

Post 183270 (missing)

(The_Animal: "Triethylsilane", Stimulants)
might be useful

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