Things are coming together but SWIM is still waiting on an item or 2. I figured that I should run a projected synth by you ahead of time to see if anything is out of place. Sassafras will be distilled via fridge compressor, isomerized in KOH/CaO.
After that the oxone reaction will be run according to the link to your write-up on rhodium's page. Will scaling this reaction 5x be a possibility in a 2L 3N RBF? The reagent's haven't been weighed and placed in the vessel(partly due to abscence of oxone), so we have no concept of how full it will get at those quantities. SWIM isn't too concerned with the amount, just achieving a working environment in the flask. If no experimental work has been done in determining a relationship in scaling:yield that could be done as well. That will take a little time to compile and complete though.
After the oxone reaction h2SO4 will be used similarly to the common peracid route. The ketone will be vacuum distilled, since no bisulfite is readilly available(SWIM is a bit picky about product purification, insisting on fractional distillation. He does this with all of his solvents prior to use, and to all of his products prior to corresponding use).
Amination will be done via Al/Hg MeAm. Nitromethane is OTC, but SWIM got lucky this week with a bit of 40% aqueous methylamine. I've read that only minor alterations have to be made to the contents(adding a litle non-iodized NaCl, restricting any other sources of water) and yields should still stay at an adequate level. In addition the reaction will be less exothermic, with obvious benefits in scalability. Am I correct in assuming this? I guess it should be noted that the aluminum source would be reynold's heavy duty foil, balled up into nuggets; and the Hg would come from mercuric nitrate(the most soluble salt of it in water....coincidence? perhaps...
). I can't see any fault in these alterations, but maybe someone with more experience would know what I don't.
Well, that's the plan. Now it's all just a matter of making it work. I have a little time before everything will come together, and i just wanted to check if all of my shit is together.