Dare I say it (hmmm... I wonder)
Pressure Pipe, Acetone!
Dammit I don't have any tryptophan or a decent device to measure the mp/bp of the products... But I've got some pictures of tyrosine and lysine going decarbed. They're definitely producing freebases, can't clean the bastards off nothing, and they have that strange smell...
Question is: purity. How much can be done.
And second question is: what does it mean when acetone is 'critical' Is that what I am thinking? equal vapour/liquid pressure? I saw somewhere someone saying that 800K makes acetone decompose, but I'm only talking about 523K, 250C. I've done it twice in a standard .068mm thick galvanised house pipe 3" long and I raised the temp to 250 and then turned it off. I first tested the temp thing slowly, first at 100 in boiling water (hey, my water boils at 101, does that mean it's heavy water... nah think my thermo's a bit wrong. I am virtually sea level here though) Then at 150 in the oven. Then 200. Then 250. When it peaks at 250 I freak and switch the whole damn thing off and let it cool slowlike. Nobody's told me whether critical acetone is dangerous, contained in a pipe. I want to emphasise that nobody should fool around with flammable stuff near flames. Banish thine gas stove from thine mind. Do not use gas stove. Bad. [spank] [dammit] very bad kiddies
Test your pipe, at 100, make sure it don't leak. At 150 - make sure it don't leak. At 200, make sure it don't leak. at 250 make sure it don't leak. I don't think leaking acetone is good at 250, methinks it could flash. I've seen hexane/pentane/heptane/octane go boom inside oven at 150. Bee Veeeerry Careful. Must not leak. Get super duper high-grade multigrips of monkey wrenches to tighten the pipe with. It's gotta be hermetic, or there could be trouble. With sufficent tension, and adequate PTFE tape, it should be all good.
I thinks that 250C acetone is supercritical. It will break off those COO's quick smart. Including cooldown, and assuming pressure test passing, this process with high-pressure (maybe even supercritical) acetone is over in about half an hour. As long as you've got pure aminos, it's a good 90% yield at least.
Dammit, would someone with better equipment and equivalent brains check out the high pressure acetone idea? If only someone could give a definitive pressure figure on a 2/3 full pipe sealed with acetone. Dwarfer says 1000psi, which is really stretching it on the pipe, I says 100psi.
I WANT AN ANSWER GODDAMMIT! you guys, cmon, take up the challenge, if you're so sure this bee's trippin, put the figures on the table. And if he's not trippin, put the figures on the table. This is worth proving. DMT synthesis without needing a reflux to make tryptamine. That is a good thing. IS IT SAFE? I want some definitive answers.
Next is to see if a non-reflux method can make it into dimethyl... then we are really talkin. Catalytic hydogenation? electrolytic hydrogenation? doable? or not?
I know naaaathing.