The Vespiary

The Hive => Chemicals & Equipment => Topic started by: Cyrax on June 06, 2002, 12:09:00 AM

Title: methoxyacetyl chloride
Post by: Cyrax on June 06, 2002, 12:09:00 AM: Is it suspicious to buy methoxyacetyl chloride? Is it a watched chemical?
Title: I'd say that is obscure enough to be safe.
Post by: Rhodium on June 06, 2002, 12:36:00 AM: I'd say that is obscure enough to be safe.
Title: Curious
Post by: PrimoPyro on June 06, 2002, 02:49:00 AM: Methoxyacetyl chloride...

CH3-O-CH2-CO-Cl correct?

What use would this have clandestinely? Just curious.

PrimoPyro
Title: Well, you can use it instead of propionyl ...
Post by: Cyrax on June 06, 2002, 01:39:00 PM: Well, you can use it instead of propionyl chloride or propionic anhydride to acylate 1-phenethyl-4-(N-phenylamino)-piperidine to get a nice fentanyl analog with an ED50 of 0.08 mg / kg. Propionyl chloride is suspicious (right?), so I think this is a good alternative.

Or you can use 2-furoyl chloride to the amine. That compound will certainly not be suspicious. Then the ED50 is 0.02 mg / kg.
Title: Fentanalogs
Post by: Rhodium on June 06, 2002, 01:44:00 PM: Cyrax: Very interesting! Refs?
Title: ... and bypass some analogue laws !
Post by: Nemo_Tenetur on June 06, 2002, 01:45:00 PM: Very good idea!
Although somewhat weaker, you can get around U.K. generic definition (and maybe same in some other countries) ;)
Title: Check it out: US patent 4584303.
Post by: Cyrax on June 06, 2002, 06:17:00 PM: Check it out: US patent 4584303. You will find a real treasure of fentanyl analogs. It is one of the best fentanyl patents I have read.

Too weak: I think it is strong enough to not kill yourself during the synthesis. If you want a stronger compound: simply use o-fluoroaniline instead of aniline. Then the ED50 will be 0.0077 mg / kg. But I forsee that the yield of the acylation will be lower, since that lovely little fluorine atom will suck the free electron pair of the nitrogen into the aryl ring :) (resonance)