The Vespiary

The Hive => Newbee Forum => Topic started by: aleph on October 28, 2003, 12:27:00 AM

Title: Sodium Borohydride vs Sodium Cyanoborohydride
Post by: aleph on October 28, 2003, 12:27:00 AM

Anyone have a clue whether sodium borohydride rather than sodium cyanoborohydride will work in Strike's (Total Synthesis II) method #1 (page 98)?

A post I have seen indicates it may be a possibility, but indicates the use of methylamine gas.  I was hoping for the easy reaction in Strike's book without cyanoborohydride.

Title: Borohydride will work with methylamine just...
Post by: cublium on October 28, 2003, 06:50:00 AM

Borohydride will work with methylamine just fine althought cyanoborohydride will give slightly higher yields(it doesn't reduce ketone to alcohol,which borohydride does,but only imine to amine).

Title: Thanks
Post by: aleph on October 29, 2003, 11:32:00 PM

Thanks for the info.