The only material I've ever seen about biosynthesis of LSD used a suspended culture of ergot (Claviceps purpura), and weighted the nutrient with precursors of ergotamine (I think, but it was def one of the lysegic acid amide alkaloids that involved amide substitution), but so that instead of the group(s) that would have been substituted into the amide, the nutrients were weighted in favour of formation of the diethylamide (i recall ut involved adding amino acids as the substrate for the diethylamide).
I can't remember any yield figures, but it was sucessful in producing LSD as an "artificial" alkaloid. I don't suppose that you have to get much of a yield to make it worthwile, but its separation from the organic soup would require a lot of time and effort