...18-methoxycoronaridine exerts its anti-addictive effects via a reversal of the neuroadapations mediating increased incentive salience for drugs of abuse...
Maybe in addition to its apparent anti-addiction potential, could it be used by hedonists (read: people like me) to resensitize the CNS to 5-HT-ergic and DA-ergic (read: almost any enjoyable) drugs?
The article:
Abrams, Michael. "The End Of Craving." Discover May 2003 (vol. 24 : no. 5) pgs 24-5.
Page of citations of 18-MC research:
http://www.ibogaine.org/18-mc/ (http://www.ibogaine.org/18-mc/)
http://userpages.umbc.edu/~jfreed1/Ibogaine.html (http://userpages.umbc.edu/~jfreed1/Ibogaine.html)
http://userpages.umbc.edu/~jfreed1/Ibogaine.pdf (http://userpages.umbc.edu/~jfreed1/Ibogaine.pdf)