The Vespiary

The Hive => Newbee Forum => Topic started by: eXcidium on May 05, 2004, 08:05:00 AM

Title: a-thujone
Post by: eXcidium on May 05, 2004, 08:05:00 AM

Hi

Does anyone have idea if this substances (alpha-thujone or beta-thujone) have a synthesis published somewhere?

Thanks

Title: Thujone
Post by: hest on May 05, 2004, 11:27:00 AM

It's made in the nature, you can by it for almost free. And I'm sure that the total synthesis i loooong and hard to come over.

Title: here
Post by: eXcidium on May 06, 2004, 01:23:00 AM

Hey hest - and thanks

Well buy it for almost free.. tthat would be good
Wormwood oil - 99% thujone (1L) = $300
I wouldn't call that cheap :p

The synthesis would be a best way, i think

Title: Synthesis
Post by: Aurelius on May 06, 2004, 04:12:00 AM

synthesis of thujone vs its purchase at $300.00/L  ......

buy the stuff- saves time, MONEY, effort, requires no chemicals, labs, glassware, etc.

are you familiar with synthesis at all?

Title: Indeed
Post by: eXcidium on May 06, 2004, 04:20:00 AM

Indeed i am.

I have a nice lab setup (wich i bought in my college days), and have been boughting new stuff

Also reagents or no problem since chemistry (more like genetics/biochemistry) is my area

Glad if you could supply a synthesis of the said subtance


Cheers

Title: Thujone
Post by: Rhodium on May 06, 2004, 06:20:00 AM

(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000504962-file_j6xa.gif)

As late as 1981, thujone was preferentially isolated from natural oils over synthesis... It is not especially easy to synthesize a molecule consisting of a cyclopentane-cyclopropane bicycle with two chiral alkyl groups.

Solution-phase photodecarbonylation of the bicyclo[3.1.0]hexan-3-one system
Robert S. Cooke, Gregory D. Lyon
J. Am. Chem. Soc. 103, 7317-7322 (1981)

(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_imgs/pdf.gif)

Title: thx
Post by: eXcidium on May 06, 2004, 06:25:00 AM

Thanks Rhodium.. i'll check this out

Title: These gay's make it from scrat's.
Post by: hest on May 06, 2004, 11:17:00 AM

These gay's make it from scrat's. 300$/L is free trust mee.
But Iff you synt. it from bottom Il doo will respect you werye much.

http://journal.library.iisc.ernet.in/archives/V22.html (http://journal.library.iisc.ernet.in/archives/V22.html)