I am most interested in MAO-b inhibiting beta-carbolines. Coffee has a appreciable amount of one of the most potent MAO-b inihibiting MAOI's norharman. Ironic isn't it.
Food Additives and Contaminants
Document Request
Title: Identification and occurrence of the bioactive â-carbolines norharman and harman in coffee brews
Author(s): T. Herraiz
Source: Food Additives and Contaminants Volume: 19 Number: 8 Page: 748 -- 754
DOI: 10.1080/02652030210145892
Publisher: Taylor and Francis Ltd
Abstract: Norharman and harman, two heterocyclic â-carboline alkaloids with biological activity, were found in brewed coffee. Identification and analysis were carried out by HPLC-MS and RP-HPLC-fluorescence, respectively. All tested samples of brewed coffee including ground coffee, decaffeinated coffee, instant coffee and espresso contained both norharman and harman in variable amounts. Norharman was the major â-carboline alkaloid in brewed coffee at levels up to 9.34 ìg g-1 in instant ground coffee compared with harman, which had levels up to 1.67 ìg g-1. The two â-carbolines appeared to be formed during roasting of the coffee beans. It is concluded that drinking coffee is a major exogenous dietary source of these bioactive â-carboline alkaloids previously reported as mild psychoactive compounds in animal studies and in vitro co-mutagens. These results support our previous conclusion that foods containing â-carbolines are an important exogenous source of these alkaloids in humans.
Reference Links: 37
http://dandini.ingentaselect.com/vl=66450295/cl=15/nw=1/rpsv/cgi-bin/linker
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Irony has it that for I that my daily dose of amphetamine seems to be prolonged and less harsh when administered in a nice mildy strong cup of coffe with addition of equal parts of milk and a small amount of honey for that dextrose kick that amphetamines definatly highten.
I think pinolene the compound you are asking about has a MAO activity in between norharman and harmaline inhibiting MAO-A and B in same proportions. Harmaline is mostly MAO-A inhibiting while norharman is more MAO-b inhibiting and one reason why I like it more as one can see with dopamine MAO-b is its major metabolizer.
If I could I would want to find a good source of pure norharman or synth it my self. I think pure tryptophan is needed though for its formation. No methoxy groups if I remember right. Harman is more on the MAO-A side so it causes adrenaline increase and cause heart and other parts to speed up as also blood pressure which to a student trying to concentrate is not as fun.
I think meth and norharman would be a good ayhuasca combo;)